+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Development of amygdaloid cholinergic mediation of passive avoidance learning in the rat. I. Muscarinic mechanisms

Development of amygdaloid cholinergic mediation of passive avoidance learning in the rat. I. Muscarinic mechanisms

Experimental Brain Research 67(1): 61-69

Passive avoidance learning was studied in young rats 13-30 days of age following bilateral injections of saline or antimuscarinic and/or muscarinic agents into three amygdaloid nuclei.sbd.lateral (L), basolateral (BL), and cortical (CO). While acquisition was not influenced by saline injections into various other cerebral structures, it was significantly altered by similar injections into these amygdaloid nuclei, especially by those into the BL nucleus, suggesting that this nucleus is particularly involved in passive avoidance learning. Atropine induced significant deficits from as early as 13 days on. These deficits increased and were of similar strength after injections into any of the three studied nuclei until day 16; after that age, they diminished slightly following CO and L nuclei administration, while remaining substantial after BL nucleus injections at all ages, even at 30 days. No facilitatory effects could be elicited by arecoline injected alone, while arecoline could antagonize the disturbing effect of atropine, when given in combination, from day 13 on. These results suggest a muscarinic cholinergic mediation of passive avoidance learning thorugh the synaptic elements located in the basal lateral part of the amygdala in the young rat.

(PDF 0-2 workdays service: $29.90)

Accession: 005132309

Download citation: RISBibTeXText

PMID: 3622683

Related references

Development of amygdaloid cholinergic mediation of passive avoidance learning in the rat. II. Nicotinic mechanisms. Experimental Brain Research 67(1): 70-76, 1987

Development of amygdaloid cholinergic mediation of passive avoidance learning in the rat. Experimental Brain Research 67(1): 61-69, 1987

Implication of amygdaloid muscarinic cholinergic mechanisms in passive avoidance learning in the developing rat. Behavioural Brain Research 13(2): 97-106, 1984

Age-dependent improvement in passive avoidance learning of the young chick: cholinergic mediation?. Journal of Comparative and Physiological Psychology 96(3): 423-431, 1982

Changes in binding to muscarinic and nicotinic cholinergic receptors in the chick telencephalon, following passive avoidance learning. Neuroscience Letters 270(2): 75-78, July 30, 1999

Transient increase in fore brain muscarinic cholinergic receptor binding following passive avoidance learning in the young chick. Neuroscience 5(1): 169-172, 1980

Effects of anti muscarinic cholinergic drugs injected systemically or into the hippocampo entorhinal area on passive avoidance learning in young rats. Psychopharmacology 76(4): 351-358, 1982

Enhancement of passive avoidance learning through small doses of intra-amygdaloid physostigmine in the young rat. Its relation to the development of acetylcholinesterase. Developmental Psychobiology 21(6): 553-565, 1988

The 5-HT1A receptor antagonist robalzotan facilitates passive avoidance retention in male mice Possible mediation via increased cholinergic transmission. European Neuropsychopharmacology 13(Supplement 4): S401, September, 2003

The pre- and postsynaptic mechanisms of the involvement of the serotonin of the amygdaloid body in the reproduction of the conditioned passive avoidance reaction in rats. Zhurnal Vysshei Nervnoi Deiatelnosti Imeni i P Pavlova 48(3): 464-470, 1998

Pre- and postsynaptic mechanisms of the involvement of amygdaloid complex serotonin in the reproduction of a conditioned passive avoidance response in rats. Neuroscience and Behavioral Physiology 29(4): 359-363, 1999

Mediation of passive avoidance learning by nicotinic hippocampo-entorhinal components in young rats. Developmental Psychobiology 18(4): 355-366, 1985

Participation of muscarinic receptors in memory consolidation in passive avoidance learning. Acta Neurobiologiae Experimentalis 74(2): 211-217, 2015

Alterations in acetylcholine content and muscarinic cholinergic binding of various brain regions after performance of passive avoidance behaviors in mice. Biogenic Amines 7(2): 199-207, 1990

Involvement of dorsal hippocampal muscarinic cholinergic receptors on muscimol state-dependent memory of passive avoidance in mice. Life Sciences 88(25-26): 1136-1141, 2011