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Development of cerebro spinal fluid and the blood cerebro spinal fluid barrier in rabbits



Development of cerebro spinal fluid and the blood cerebro spinal fluid barrier in rabbits



Developmental Biology 68(1): 292-298



Blood plasma and CSF samples were collected from adult female rabbits (New Zealand White), newborn, and embryos at 18, 20, 24 and 28 days of gestation. Samples were analyzed for total protein using the Folin phenol reagent. During development, mean total protein of blood plasma rose sharply from 12.45-12.51 mg/ml at 18-20 days to 37.56 mg/ml at 28 days. Levels further increased to 54.06 mg/ml in the newborn and to 66.18 mg/ml in the adult. The protein concentration of CSF was constant at 5.20-5.29 mg/ml between 18 and 20 days of gestation, but steadily decreased to 3.53 mg/ml at 28 days. By birth, the CSF protein concentration was further reduced to 2.08 mg/ml, and this level differed only slightly (P < 0.05) from CSF protein values determined for adults. The blood-CSF barrier to proteins evidently begins to function by 18-20 days of gestation, and the protein concentration of CSF approaches the normal adult value soon after birth.

Accession: 005132922

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PMID: 437321


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