+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Development of stroma in malignant lymphomas of the brain compared with epidural lymphomas. An immunohistochemical study



Development of stroma in malignant lymphomas of the brain compared with epidural lymphomas. An immunohistochemical study



Acta Neuropathologica 71(1-2): 125-129



The relation of lymphoma cells to gliomesenchymal stroma within nervous tissue was studied by peroxidase-antiperoxidase immunostaining of formalin-fixed and paraffin-embedded surgical specimens for fibronectin (FN), factor VIII-related antigen and glial fibrillary acidic protein in 17 malignant non-Hodgkin lymphomas of the brain. For comparison, 9 non-Hodgkin lymphomas, 6 Hodgkin lymphomas, and 19 plasmacytomas of the spinal or cranial epidural spaces were studied with the same methods. Lymphoma cells were consistently negative for all markers. All lymphomas of the brain showed conspicuous concentric perivascular circles of immunoreactivity for FN in parts infiltrating brain tissue. Such structures are considered to derive from splitting of basal laminae of preexisting brain vessels; they were not seen in tumors of the epidural space. Cells with conspicuous FN content were found in brain as well as in epidural lymphomas. A monohistiocytic orgin of those cells was confirmed by presence of monohistiocytic markers lysozyme and .alpha.-1-anti-chymotrypsin. Thus, additional immunostaining for FN seems to be useful for detecting monohistiocytes/macophages in brain tumors.

(PDF emailed within 1 workday: $29.90)

Accession: 005135529

Download citation: RISBibTeXText

PMID: 3535355


Related references

Immunohistochemical analysis of adhesion molecules and matrix metalloproteinases in malignant CNS lymphomas: a study comparing primary CNS malignant and CNS intravascular lymphomas. Brain Tumor Pathology 25(2): 73-78, 2008

Epidural malignant lymphomas of the spine: collected experiences with epidural malignant lymphomas of the spinal canal and their treatment. Spinal Cord 46(4): 278-281, 2007

Lymphomas and pseudo lymphomas of the gastrointestinal tract a retrospective analysis including a study of immunologic markers in fifty two malignant lymphomas and five pseudo lymphomas. Archives d'Anatomie et de Cytologie Pathologiques 34(3): 143-145, 1986

Hiv related malignant lymphomas treatment and prognosis compared to classic lymphomas. Onkologie 14(SUPPL 2): 97, 1991

Immunohistochemical molecular and cytogenetic analysis of a consecutive series of 20 peripheral t cell lymphomas and lymphomas of uncertain lineage including 12 ki i positive lymphomas. Genes Chromosomes & Cancer 2(1): 27-35, 1990

Angiogenesis spectrum in the stroma of B-cell non-Hodgkin's lymphomas: An immunohistochemical and ultrastructural study. European Journal of Haematology 56(1-2): 45-53, 1996

Prognosis and treatment of malignant digestive lymphomas. I. Primary lymphomas of the digestive tract should be treated like other malignant non-Hodgkin's lymphomas. Systematic laparotomy is not indispensable. Gastroenterologie Clinique et Biologique 8(5): 430-431, 1984

Malignant lymphomas in children. A clinico-pathologic retrospective study. II. Non-Hodgkin's lymphomas. Acta Paediatrica Scandinavica 63(5): 679-686, 1974

Low grade malignant non-Hodgkin's lymphomas and peripheral pleomorphic T-cell lymphomas in childhood--a BFM study group report. Klinische Padiatrie 202(4): 258-261, 1990

Role of early splenectomy in malignant lymphomas with prominent splenic involvement (primary lymphomas of the spleen): A study of 59 cases. Cancer (Philadelphia) 71(1): 207-215, 1993

Primary gastrointestinal malignant lymphomas. A morphologic and immunohistochemical study. Cancer 55(4): 870-879, 1985

Clinicopathological and immunohistochemical study of primary orbital and conjunctival malignant lymphomas. Folia Ophthalmologica Japonica 42(6): 1330-1339, 1991