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Development of suppressor thymus derived cells in mice heavily infected with mycobacteria



Development of suppressor thymus derived cells in mice heavily infected with mycobacteria



Immunology 39(3): 367-374



Specific pathogen-free B6D2 mice were infected i.v. with 108 viable BCG, Mycobacterium habana or M. simiae and the level of tuberculin hypersensitivity to 2.5 .mu.g PPD [purified protein derivative] or cytoplasmic protein antigens (CPA) prepared from the other organisms was determined using the footpad swelling test with increasing time after infection. This was correlated with the growth or persistence of mycobacterial populations within the liver. Spleen cells were removed from these infected mice and the level of blast transformation following exposure to PHA [phytohemagglutinin], PPD or M. habana or M. simiae CPA was measured in vitro. Early in the mycobacterial infections (day 14) thymidine incorporation by the spleen cells was significantly enhanced followed by profound depression in incorporation rates as the infection progressed. Mechanism of this depressed response involved production of suppressor T [thymus-derived] cells in the spleen. In the case of the M. simiae or M. habana infection, cells capable of mediating suppression were present after 12 mo. of infection. In the BCG infection, suppressor T cells declined with time so that by 4 mo. incorporation rates were back to normal and suppressor cells were no longer detectable in spleens of the infected animals.

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