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Developmental regulation of amino acid transport in Neurospora crassa


, : Developmental regulation of amino acid transport in Neurospora crassa. Journal of Bacteriology 104(2): 689-697

Conidia of Neurospora crassa exhibit an ability to transport various amino acids against a concentration gradient. The conidial transport system has previously been characterized in terms of kinetics, competitions, and genetic control. This study describes the development of a new and highly active transport capability which is elaborated during the early stages of development but prior to evident germination. It has been named "postconidial" transport activity and represents as much as 20-fold greater initial rates as compared to those observed with conidia. Development of the postconidial transport activity requires protein synthesis and can be partially repressed when the substrate amino acid is present during the developmental preincubation period. A mutant has been utilized which exhibits normal conidial but fails to develop normal postconidial transport activity for any amino acid examined. Although temperature optimum and pH dependence are similar in conidial and postconidial systems, there is evidence that the new activity is not a simple amplification of an existing capability. This is reflected as a change in competition patterns between particular amino acids as development proceeds.


Accession: 005138657

PMID: 5489433

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Related references

Tisdal, Janet-Boone-Herbert, 1972: Mechanisms of developmental regulation of amino acid transport in Neurospora crassa

Thwaites, W.M.; Pendyala, L., 1969: Regulation of amino acid assimilation in a strain of Neurospora crassa lacking basic amino acid transport activity. Biochimica et Biophysica Acta 192(3): 455-461

Pall, M.L., 1971: Amino acid transport in Neurospora crassa. IV. Properties and regulation of a methionine transport system. A specific amino acid transport system in Neurospora crassa is described with affinity for methionine and several of its analogs. This methionine transport system has a Michaelis constant (Km) for l-methionine of about 23 M and has lower affinity...

Pall M.L., 1968: Kinetic and genetic studies of amino acid transport in neurospora abstract neurospora crassa. Genetics 60(1 PART 2): 209

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Pall, M.L., 1969: Amino acid transport in Neurospora crassa. I. Properties of two amino acid transport systems. Biochimica et Biophysica Acta 173(1): 113-127

Wiley, W.R., 1966: Amino acid transport in Neurospora crassa. BNWL-280. Bnwl Reports . U.S. Atomic Energy Commission: 92-95

Wolfinbarger, L.; Debusk, A.G., 1971: Molecular transport. I. In vivo studies of transport mutants of Neurospora crassa with altered amino acid competition patterns. The active transport of metabolites by Neurospora crassa conidia has been studied by both kinetic and genetic methods. Transport, reported to be dependent on temperature, pH, and an energy source, is shown to accumulate amino acids by (1) a system...

Sikora, L.M.rzluf, G., 1982: Regulation of L-amino acid axidase and of D-amino acid oxidase in Neurospora crassa Fungi. MGG molecular and general genetics86(1): 33-39

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