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Dextro amphetamine induced hypo thermia and hyper motility in rats changes after systemic administration of beta endorphin



Dextro amphetamine induced hypo thermia and hyper motility in rats changes after systemic administration of beta endorphin



Peptides (Orlando) 1(2): 179-186



Systemically administered .beta.-endorphin was tested in rats for its ability to modify the hypothermia and hypermotility induced by d-amphetamine. Colonic temperature and motor activity were measured in a cold (4.degree. C) ambient temperature in animals given i.p. injections of .beta.-endorphin (0.1, 1.0 or 3.0 mg/kg), naloxone (10 mg/kg) or morphine (30 mg/kg). The same measurements were taken in animals given .beta.-endorphin (1.0 mg/kg) in combination with naloxone or saline pretreatment and d-amphetamine (15 mg/kg) or saline post-treatment. Morphine alone had a biphasic effect on thermoregulation, but did not affect d-amphetamine-induced hypothermia. Activity scores were decreased by morphine, in both d-amphetamine and saline treated animals. The thermal response of rats to .beta.-endorphin alone was variable, depending on dosage, but all 3 dosages partially blocked the hypothermic effect of d-amphetamine. Naloxone blocked the thermal effects of both .beta.-endorphin and d-amphetamine. Motor activity tended to be decreased by naloxone, regardless of amphetamine treatment, but .beta.-endorphin tended to increase activity in amphetamine-treated animals and reduce it in saline-treated controls. In their actions on both thermoregulation and activity, naloxone and .beta.-endorphin appeared to interact independently with d-amphetamine, often producing effects in the same direction; in combination, they tended to be mutually inhibitory.

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Accession: 005139820

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