Dibekacin assay in serum by automated fluorescence polarization immunoassay (Abbott Tdx) : comparison with high-performance liquid chromatography, substrate-labelled fluorescent immunoassay and radioimmunoassay

Rollman, B.; Van Der Auwera, P.; Tulkens, P.M.

Journal of Pharmaceutical and Biomedical Analysis 4(1): 53-61

1986


ISSN/ISBN: 0731-7085
PMID: 16867630
Accession: 005146620

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Abstract
An immunoassay based on fluorescence polarization detection (FPIA) has been recently adapted for dibekacin. This has been compared with a reference method (high-performance liquid chromatography), and two other methods used in clinical laboratories for monitoring this aminoglycoside, namely substrate-labelled fluorescent immunoassay (SLFIA) and radioimmunoassay (RIA). FPIA was fast and more reliable than SLFIA or RIA, and offered therefore superior performance. However, its nominal cost per assay is high.