Section 6
Chapter 5,149

Dietary sucrose and cholesterol metabolism 1. effects of various nutritional conditions on serum and liver cholesterol levels in rats fed a low cholesterol diet

Nakagawa, Y.; Tsuji, K.; Tsuji, E.; Suzuki, S.

Japanese Journal of Nutrition 38(4): 197-206


Accession: 005148929

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The effects of replacing corn starch with sucrose in a cholesterol-free diet on serum and liver cholesterol levels were studied in Sprague-Dawley rats under various dietary conditions and for different feeding periods. There was no difference between the growth rate produced by a diet with sucrose and that produced by a diet with cornstarch, both as the sole carbohydrate source, for 1O to 28 days' feeding. Body weight gain and tissue weight of animals were significntly affected by diets composed of different amounts of milk casein. Sucrose in the diet led to greater enlargement of liver or perirenal adipose tissue than did cornstarch. Nutritional factors, e.g., the dietary source and levels of carbohydrate, fat and protein showed no demonstrable effects on the concentrations of cholesterol in serum. In a diet with adequate protein, serum cholesterol tended to increase with sucrose regardless of the difference of dietary fat sources. In a low protein diet, serum cholesterol tended to increase with the starch. The whole amount of liver cholesterol was remarkably influenced by dietary carbohydrate sources. Concomitant feeding of the sucrose diet with the lard or starch diet with safflower oil significantly elevated the cholesterol contents of the liver. When sucrose in the diet replaced the starch, higher triglyceride concentrations in serum and liver were observed.

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