+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Differences in susceptibility to infection with treponema pallidum between 5 strains of guinea pig

, : Differences in susceptibility to infection with treponema pallidum between 5 strains of guinea pig. Genitourinary Medicine 61(1): 21-26

Groups of 10 young male guinea pigs of inbred strains 2 and 13 and outbred strains Hartley A, Hartley B, and 1 deficient in the 4th complement component C4D were infected intradermally with 80 .times. 106 T. pallidum (Nichols). The course of infection and production of antitreponemal antibody were examined. Strain C4D guinea pigs were the most susceptible to infection (100%); inbred strains 2 and 13 and outbred strain Hartley B showed 80-90% symptomatic infection; and the Hartley A strain was the least susceptible to infection (10%). Strain 13 animals responded with the highest antitreponemal antibody activity, and the Hartley A strain with the lowest. The results suggest that genetic factors or complement, or both, may influence the degree of susceptibility to infection with T. pallidum in guinea pigs.

Accession: 005151018

Submit PDF Full Text: Here

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Wicher, K.; Wicher, V.; Gruhn, R.F., 1985: Differences in susceptibility to infection with Treponema pallidum (Nichols) between five strains of guinea pig. Groups of 10 young male guinea pigs of inbred strains 2 and 13 and outbred strains Hartley A, Hartley B, and one deficient in the fourth component of complement (C4D) were infected intradermally with 80 X 10(6) Treponema pallidum (Nichols). The co...

Gruhn R., 1984: Susceptibility of various strains of guinea pigs to treponema pallidum nichols infection. Abstracts Of The Annual Meeting Of The American Society For Microbiology: Stract B183

Wicher K.; Zabek J.; Wicher V.; Hannett G., 1991: The role of treponema pallidum specific and crossreacting antibodies in protection against treponema pallidum infection in guinea pig. Abstracts of the General Meeting of the American Society for Microbiology 91: 124

Pavia, C.S., 1986: Enhanced primary resistance to Treponema pallidum infection and increased susceptibility to toxoplasmosis in T-cell-depleted guinea pigs. Strain 2 guinea pigs made T-cell deficient by thymectomy and irradiation and protected with syngeneic bone-marrow cells (TXB guinea pigs) have a surprisingly high level of resistance to cutaneous syphilis and to the dissemination of treponemes to...

Leader, B.T.; Hevner, K.; Molini, B.J.; Barrett, L.K.; Van Voorhis, W.C.; Lukehart, S.A., 2003: Antibody responses elicited against the Treponema pallidum repeat proteins differ during infection with different isolates of Treponema pallidum subsp. pallidum. Variation in the expression of the different Tpr proteins in the syphilis spirochete, Treponema pallidum subsp. pallidum, may have important implications in its ability to evade host immune detection and cause persistent infection. In the present...

Mikalová, L.; Strouhal, M.; Čejková, D.; Zobaníková, M.; Pospíšilová, P.; Norris, S.J.; Sodergren, E.; Weinstock, G.M.; Šmajs, D., 2011: Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains: most of the genetic differences are localized in six regions. The genomes of eight treponemes including T. p. pallidum strains (Nichols, SS14, DAL-1 and Mexico A), T. p. pertenue strains (Samoa D, CDC-2 and Gauthier), and the Fribourg-Blanc isolate, were amplified in 133 overlapping amplicons, and the restri...

Zinsser, H.; Hopkins, J.G.; McBurney, M., 1916: Studies On Treponema Pallidum And Syphilis : Iii. The Individual Fluctuations In Virulence And Comparative Virulence Of Treponema Pallidum Strains Passed Through Rabbits. 1. As regards these strains, at least, there is no consistent change, either increase or decrease, of rabbit pathogenicity during progressive rabbit passage. 2. There is no difference in pathogenicity between these different strains, although some...

Graves, S., 1979: Susceptibility of rabbits to Treponema pallidum after infection with Mycobacterium bovis. Rabbits stimulated with Mycobacterium bovis (strain BCG) one month before challenge with Treponema pallidum (Nichols) did not show any modification in their development of syphilitic lesions. A second infection with BCG given at the same time and...

Schouls L.M.; Van Der Heide H.G.J.; Van Embden J.D.A., 1991: Characterization of the 35 kilodalton treponema pallidum ssp pallidum recombinant lipoprotein tmpc and antibody response to lipidated and nonlipidated treponema pallidum antigens. The gene encoding the 35-kDa immunogenic Treponema pallidum subsp. pallidum (T. pallidum) membrane protein C, TmpC, was cloned, sequenced, and expressed in Escherichia coli. The deduced amino acid sequence carries an N-terminal signal sequence wit...

Sayahtaheri S.; Cox D.L., 1990: Identification of treponema pallidum polypeptides a comparative study between the protein profiles of in vitro cultivated and in vivo propagated treponema pallidum ssp pallidum by two dimensional sds polyacrylamide gel electrophoresis. Abstracts of the Annual Meeting of the American Society for Microbiology 90: 213