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Differences in susceptibility to infection with treponema pallidum between 5 strains of guinea pig


Genitourinary Medicine 61(1): 21-26
Differences in susceptibility to infection with treponema pallidum between 5 strains of guinea pig
Groups of 10 young male guinea pigs of inbred strains 2 and 13 and outbred strains Hartley A, Hartley B, and 1 deficient in the 4th complement component C4D were infected intradermally with 80 .times. 106 T. pallidum (Nichols). The course of infection and production of antitreponemal antibody were examined. Strain C4D guinea pigs were the most susceptible to infection (100%); inbred strains 2 and 13 and outbred strain Hartley B showed 80-90% symptomatic infection; and the Hartley A strain was the least susceptible to infection (10%). Strain 13 animals responded with the highest antitreponemal antibody activity, and the Hartley A strain with the lowest. The results suggest that genetic factors or complement, or both, may influence the degree of susceptibility to infection with T. pallidum in guinea pigs.


Accession: 005151018



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