EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Differences in susceptibility to quinolones of outer membrane mutants of Salmonella typhimurium and Escherichia coli


Antimicrobial Agents and ChemoTherapy 29(3): 535-538
Differences in susceptibility to quinolones of outer membrane mutants of Salmonella typhimurium and Escherichia coli
The mechanism of penetration of quinolones through the bacterial outer membrane was studied with lipopolysaccharide-deficient and porin-deficient mutants. The data indicated that the lipopolysaccharide layer might form a permeability barrier for hydrophobic quinolones such as nalidixic acid but not for hydrophilic quinolones such as norfloxacin and ciprofloxacin. The results also showed that quinolones with a low relative hydrophobicity appeared to permeate through OmpF porin, whereas quinolones with a low relative hydrophobicity appeared to permeate through OmpF porin, whereas quinolones with a high relative hydrophobicity appeared to permeate through both OmpF porin and phospholipid bilayers.


Accession: 005151023

PMID: 3521490

DOI: 10.1128/AAC.30.2.342



Related references

Activity of KB-5246 against outer membrane mutants of Escherichia coli and Salmonella typhimurium. Antimicrobial Agents and ChemoTherapy 34(7): 1323-1325, 1990

Salmonella typhimurium and Escherichia coli mutants with increased outer membrane permeability to hydrophobic compounds. Biochimica et Biophysica Acta 988(3): 377-387, 1989

In vitro antibacterial activities of tosufloxacin against and uptake of tosufloxacin by outer membrane mutants of Escherichia coli, Proteus mirabilis, and Salmonella typhimurium. Antimicrobial Agents and ChemoTherapy 36(9): 2030-2036, 1992

Comparison of Escherichia coli K-12 outer membrane protease OmpT and Salmonella typhimurium E protein. Journal of Bacteriology 171(5): 2903-2905, 1989

Comparison of outer membrane porin proteins produced by Escherichia coli and Salmonella typhimurium. Journal of Bacteriology 142(3): 1019-1022, 1980

The apeE gene of Salmonella typhimurium encodes an outer membrane esterase not present in Escherichia coli. Journal of Bacteriology 180(14): 3517-3521, 1998

Action of polymyxin B on bacterial membranes: morphological changes in the cytoplasm and in the outer membrane of Salmonella typhimurium and Escherichia coli B. Antimicrobial Agents and ChemoTherapy 8(1): 95-104, 1975

Elimination of plasmids pKM 101 and F'lac from Salmonella typhimurium and Escherichia coli by bisammonium salt. The effect of outer membrane pattern. Folia Microbiologica 36(3): 240-245, 1991

Enzymes of phospholipid metabolism: localization in the cytoplasmic and outer membrane of the cell envelope of Escherichia coli and Salmonella typhimurium. Biochimica et Biophysica Acta 249(2): 628-635, 1971

Arrangement of the maltose-inducible major outer membrane proteins, the bacteriophage lambda receptor in Escherichia coli and the 44 K protein in Salmonella typhimurium. Febs Letters 99(1): 77-80, 1979