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Differences in the ability of salbutamol to prevent and reverse ltc 4 induced contractions of the guinea pig isolated trachea influence of 1 serine borate

, : Differences in the ability of salbutamol to prevent and reverse ltc 4 induced contractions of the guinea pig isolated trachea influence of 1 serine borate. European Journal of Pharmacology 126(3): 323-328

In the presence of 1-serine borate, salbutamol was much more effective in reversing rather than preventing LTC4-induced contractions of guinea-pig trachea. This suggests that different mechanisms are involved in initiating versus maintaining LTC4-induced contractions. In addition, the ability of salbutamol pretreatment to prevent LTC4-induced contractions was reduced substantially in the presence of 1-serine borate, suggesting that the metabolites of LTC4 (LTD4 and LTE4) are more sensitive to inhibition by .beta.-adrenoceptor agonists than is LTC4 itself.

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