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Differences in the ability of salbutamol to prevent and reverse ltc 4 induced contractions of the guinea pig isolated trachea influence of 1 serine borate


, : Differences in the ability of salbutamol to prevent and reverse ltc 4 induced contractions of the guinea pig isolated trachea influence of 1 serine borate. European Journal of Pharmacology 126(3): 323-328

In the presence of 1-serine borate, salbutamol was much more effective in reversing rather than preventing LTC4-induced contractions of guinea-pig trachea. This suggests that different mechanisms are involved in initiating versus maintaining LTC4-induced contractions. In addition, the ability of salbutamol pretreatment to prevent LTC4-induced contractions was reduced substantially in the presence of 1-serine borate, suggesting that the metabolites of LTC4 (LTD4 and LTE4) are more sensitive to inhibition by .beta.-adrenoceptor agonists than is LTC4 itself.


Accession: 005151054

PMID: 3093250

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Related references

Hay, D.W.; Muccitelli, R.M.; Wilson, K.A.; Wasserman, M.A.; Torphy, T.J., 1986: Differences in the ability of salbutamol to prevent and reverse LTC4-induced contractions of the guinea-pig isolated trachea: influence of l-serine borate. In the presence of l-serine borate, salbutamol was much more effective in reversing rather than preventing LTC4-induced contractions of guinea-pig trachea. This suggests that different mechanisms are involved in initiating versus maintaining LTC4-...

Charette, L.; Jones, T.R., 1987: Effects of L-serine borate on antagonism of leukotriene C4-induced contractions of guinea-pig trachea. The antagonist activity of three leukotriene D4 (LTD4) receptor antagonists and a number of bronchodilators was determined against LTC4-induced contractions of guinea-pig isolated tracheal chains in the absence and presence of the gamma-glutamyltr...

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Hand, J.M.; Schwalm, S.F., 1987: Pharmacological comparison of L-serine borate and glutathione as inhibitors of metabolism of LTC4 to LTD4 by the isolated guinea pig trachea. Cumulative dose-response curves to leukotriene C4 (LTC4) and leukotriene D4 (LTD)4 were obtained on indomethacin (5 microM) treated isolated guinea pig tracheal spiral strips. LTC4 curves, in the presence of either glutathione (GSH; 10 mM) or L-se...

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