+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Differences in the action of the ergot derivatives bromocriptine lisuride and lsd on the acetylcholine turnover in striatum and the mesolimbic structures of rat brain

, : Differences in the action of the ergot derivatives bromocriptine lisuride and lsd on the acetylcholine turnover in striatum and the mesolimbic structures of rat brain. Biogenic Amines 2(4): 305-316

The effects of the ergot derivatives bromocriptine, lisuride and LSD on the acetylcholine turnover in striatum and mesolimbic structures of rat brain were estimated by using the finite differences method. The acetylcholine and choline contents were measured radioenzymatically. After intravenous pulse injection of [3H] choline the radioactivity of both [3H] acetylcholine and [3H] choline was measured in the above brain areas. After bromocriptine administration (30 mg/kg i.p.) the acetylcholine turnover was decreased in striatum, nucleus accumbens and olfactory tubercle, respectively. Both pretreatment with lisuride (0.4 mg/kg i.p.) and LSD (0.1 mg/kg i.p.) led to an increase in the acetylcholine turnover in the mesolimbic nuclei, whereas the striatum was unaffected by these drugs. The effects of bromocriptine on the rate of cholinergic activity provides further evidence for an inhibitory dopaminergic modulation of cholinergic interneurons in the striatum and in the mesolimbic nuclei. The effects of lisuride and LSD on cholinergic neurons in the mesolimbic areas appear to be mediated through a preferential action on dopaminergic and serotoninergic autoregulatory processes in the ventral tegmental area and in the raphe nuclei, respectively, leading to an disinhibition of cholinergic neurons. The lack of modification of the acetylcholine turnover in the striatum after both drugs refers to several pharmacological and functional differences between the nigrostriatal and mesolimbic dopamine systems. The differential response of striatal and mesolimbic dopamine systems to various drugs appears to be due to differences in the modulation of dopamine synthesis and firing rate of dopamine neurons consequent to differences in autoregulatory processes and negative feed back mechanisms.

Accession: 005151064

Submit PDF Full Text: Here

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Horowski, R., 1978: Differences in the dopaminergic effects of the ergot derivatives bromocriptine, lisuride and d-LSD as compared with apomorphine. European Journal of Pharmacology 51(2): 157-166

Langnickel, R.; Bluth, R.; Oelssner, W., 1983: Various dose-dependent influences of apomorphine on the acetylcholine turnover in striatum and mesolimbic areas of rat brain. The content of acetylcholine and choline and the acetylcholine turnover rates were determined in olfactory tubercle, n. accumbens, striatum and hippocampus after the administration of various doses of apomorphine. Whereas apomorphine failed to cha...

Kehr, W., 1977: Effect of lisuride and other ergot derivatives on monoaminergic mechanisms in rat brain. The effects of the ergot derivative lisuride hydrogen maleate on synthesis, turnover and receptor activity of monoamines were compared with those of LSD, methysergide, yohimbine and methiothepin. In the dopamine (DA) rich areas, c. striatum and me...

Horowski, R., 1979: Hypothermic action of lisuride in rats and differences to bromocriptine in the antagonistic effect of neuroleptics. The semisynthetic ergot derivative lisuride induced dose- and time-dependent hypothermia in rats placed in a cold environment (+4 degrees C). As regards dosage, lisuride was more than 100 times more effective in this test model than bromocriptine....

Kehr W., 1977: Effect of lisuride and other ergot derivatives on mono aminergic neuro transmission in rat brain. Naunyn-Schmiedeberg's Archives of Pharmacology 297(SUPPL II): R54

Wachtel H.; Dorow R., 1983: Dual action on central dopamine function of trans di hydro lisuride a 9 10 di hydrogenated analog of the ergot dopamine agonist lisuride. Transdihydrolisuride (TDHL), a 9,10-dihydrogenated analog of the ergot dopamine (DA) agonist lisuride (LIS), was investigated for its influence on central dopaminergic functions in rats and mice after single i.p. administration. TDHL (0.39-25 mg/k...

de Belleroche, J.; Gardiner, I.M., 1983: Action of apomorphine, bromocriptine and lergotrile on gamma-aminobutyric acid and acetylcholine release in nucleus accumbens and corpus striatum. The effect of three dopamine agonists, apomorphine, bromocriptine and lergotrile, was tested on the release of gamma-aminobutyric acid, (GABA) and acetylcholine (ACh) from tissue slices of rat nucleus accumbens and striatum. All three agents in vi...

Carruba, M.O.; Ricciardi, S.; Müller, E.E.; Mantegazza, P., 1980: Anorectic effect of lisuride and other ergot derivatives in the rat. Three ergot derivatives, lisuride, lergotrile and bromocriptine, given to rats trained to eat 4 h a day, induced a dose- and time-related anorexia. They were more potent in this context than either amphetamine or fenfluramine. Lisuride and lergotr...

Anonymous, 2002: DA agonists -- ergot derivatives: lisuride: management of Parkinson's disease. Movement Disorders 17 Suppl 4: S74-S78

Lapka, R.; Smolík, S.; Franc, Z., 1984: Radioreceptor assay for ergot derivatives, transdihydrolisuride and lisuride, in biological fluids. The development of a sensitive radioreceptor assay (RRA) for transdihydrolisuride (TDHL) and lisuride, as well as the synthesis of tritiated TDHL, is described. The method is based upon the competition between 3H TDHL and TDHL or lisuride for rat...