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Differences in the antigenic structure of chromatin from rat liver and hepatoma cells


, : Differences in the antigenic structure of chromatin from rat liver and hepatoma cells. Eksperimental'naya Onkologiya 6(3): 38-42

Differences in antigenic structure of chromatin from normal and tumor cells were studied using rabbit antibodies against chromatin of the rat liver, Zaidela ascites hepatoma and solid hepatoma 27 cells. Carcinogenesis is accompanied by loss of a part of normal liver antigens. All the antigens which are not indicated in solid hepatoma were not detected in ascites tumor, too. The latter is deficient in some antigens common for the normal liver and solid hepatoma cells. Chromatin of both hepatomas contains antigens which are not detected in this tumor only. At least some antigens of tumor cells are not found in regenerating liver and in liver cells of newborn rats. Antigenic properties of liver cells chromatin in old (30 mo.) rats approach those of hepatoma cells chromatin.

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