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Differences in the behavioral effects of single stage and serial lesions of the hippocampus


Experimental Neurology 53(2): 339-354
Differences in the behavioral effects of single stage and serial lesions of the hippocampus
The behavior of rats with serial destruction of the hippocampus in different topographical configurations and temporal sequences was compared to that of appropriate 1-stage control groups. Animals that had partial bilateral damage at each operation were superior to 1-stage controls in passive avoidance and reversal learning. Animals that had unilateral lesions at the 1st stage of surgery, followed by destruction in the contralateral hippocampus at the 2nd stage, differed from controls in passive avoidance behavior only. In alternation tests, the performance of serial and 1-stage groups was statistically indistinguishable. One-stage operated animals allowed different lengths of postoperative convalescence prior to testing differed only in the spontaneous alternation tests. Serial recovery mechanisms and concepts of brain function were discussed.


Accession: 005151100

PMID: 976404



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