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Differences in the blast cell sensitivity to cytostatic drugs in various acute leukemia types and their clinical implications

, : Differences in the blast cell sensitivity to cytostatic drugs in various acute leukemia types and their clinical implications. Neoplasma (Bratislava) 31(3): 291-298

In 80 patients with AML [acute myeloblastic leukemia], ALL [acute lymphocytic leukemia], BC-CML [blast crisis of chronic myelocytic leukemia] and other proliferative blood diseases, the sensitivity of blast cells to cytostatics (vincristine, cytosine arabinoside, daunorubicin, l-asparaginase, hydrocortisone) was determined. The studies were made with the use of liquid scintillation measuring the inhibition of 3H-TdR [thymidine] incorporation induced by the cytostatics tested. The method makes it possible to demonstrate individual reactivity of acute leukemia blasts to cytostatics. Variations in the individual sensitivity to cytostatics were mostly seen in AML and BC-CML, less often in acute lymphocytic leukemia.

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