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Differences in the capacity for repair of dna damages in human cells chronically infected with rubella virus


, : Differences in the capacity for repair of dna damages in human cells chronically infected with rubella virus. Voprosy Virusologii (5): 580-583

Centrifugation of cell lysates in alkaline sucrose gradients and chromatography on hydroxyapatite columns were used to demonstrate inhibition of mitomycin C-induced DNA damages at the stage of reunification of single-strand breaks of DNA in human [laryngeal carcinoma] HEp-2 cell cultures chronically infected with rubella virus. Repair of single-strand breaks of DNA caused by bleomycin occurs with similar intensity both in chronically infected and noninfected HEp-2 cultures. The chronic course of infection in human cells may lead to disorders in repair synthesis of cellular DNA and/or is possibly due to a disconnected effect of repair enzymes in this system.

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Kolonina, I.V.; Desiatskova, R.G.; Vasil'eva, I.M.; Zasukhina, G.D., 1983: Difference in the capacity to repair DNA damage in human cells chronically infected with the rubella virus. Centrifugation of cell lysates in alkaline sucrose gradients and chromatography on hydroxyapatite columns were used to demonstrate inhibition of reparation of mitomycin C-induced DNA damages at the stage of reunification of single-strand breaks of...

Zasukhina, G.D.; Bogomolova, N.N.; Vostrova, N.G.; Kolonina, I.V.; Desiatskova, R.G., 1981: Inhibition of the process of 4-nitroquinoline-1-oxide-induced DNA break repair in chronically virus-infected human cells. Inhibition of DNA resynthesis after treatment of cell culture with 4-nitroquinoline-1-oxide was found to be due not to the induction of virus mutants repressing this system but to the selection in the cell population of cells predominantly with pa...

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