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Differences in the capacity for repair of dna damages in human cells chronically infected with rubella virus


Voprosy Virusologii (5): 580-583
Differences in the capacity for repair of dna damages in human cells chronically infected with rubella virus
Centrifugation of cell lysates in alkaline sucrose gradients and chromatography on hydroxyapatite columns were used to demonstrate inhibition of mitomycin C-induced DNA damages at the stage of reunification of single-strand breaks of DNA in human [laryngeal carcinoma] HEp-2 cell cultures chronically infected with rubella virus. Repair of single-strand breaks of DNA caused by bleomycin occurs with similar intensity both in chronically infected and noninfected HEp-2 cultures. The chronic course of infection in human cells may lead to disorders in repair synthesis of cellular DNA and/or is possibly due to a disconnected effect of repair enzymes in this system.


Accession: 005151127



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