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Differences in the capacity for repair of dna damages in human cells chronically infected with rubella virus

, : Differences in the capacity for repair of dna damages in human cells chronically infected with rubella virus. Voprosy Virusologii (5): 580-583

Centrifugation of cell lysates in alkaline sucrose gradients and chromatography on hydroxyapatite columns were used to demonstrate inhibition of mitomycin C-induced DNA damages at the stage of reunification of single-strand breaks of DNA in human [laryngeal carcinoma] HEp-2 cell cultures chronically infected with rubella virus. Repair of single-strand breaks of DNA caused by bleomycin occurs with similar intensity both in chronically infected and noninfected HEp-2 cultures. The chronic course of infection in human cells may lead to disorders in repair synthesis of cellular DNA and/or is possibly due to a disconnected effect of repair enzymes in this system.

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