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Differences in the cardiac effects of isoproterenol between stroke prone and control rats


, : Differences in the cardiac effects of isoproterenol between stroke prone and control rats. Drug Development Research 6(1): 85-90

Plasma levels of enzymes that reflect cardiac damage [glutamate-oxaloacetate transaminase (GOT), lactate dehydrogenase (LDH) and .alpha.-hydroxybutyrate dehydrogenase (.alpha.-HBDH)], of insulin, and of glucose were compared in stroke-prone (SHR-DP) and control (WKY) rats 4 h after injection of isoproterenol (30 mg/kg s.c.). Heart weights and histology were studied 24 h after isoproterenol injection. Isoproterenol produced increases in GOT, LDH and .alpha.-HBDH in both SHR-SP and WKY rats, but these changes were more pronounced (about twice as great) in SHR-SP than in WKY. Plasma glucose levels were also increased to a greater extent in SHR-SP (1.54 .+-. 0.02 to 3.57 .+-. 0.16 g/l) than in WKY (1.60 .+-. 0.04 to 2.37 .+-. 0.08 g/l) after injection of isoproterenol. Basal (plasma) insulin level was higher in WKY (2.46 .+-. 0.3 ng/l) than in SHR-SP (1.0 .+-. 0.1 ng/l) and injection of isoproterenol increased this value to a greater extent in WKY (to 4.5 .+-. 1.2 ng/l) than in SHR-SP (to 1.2 .+-. 0.1 ng/l). Cardiac edema induced by isoproterenol, determined as changes in heart weight and by histology, did not differ between SHR-SP and WKY. Marked differences in plasma parameters and in responsiveness to isoproterenol evidently exist between SHR-SP and WKY rats, thus providing a useful model for studying agents that might be used to prevent cardiac pathology.

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