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Differences in the effects of 6 hydroxy dopamine on rat learning after ventricular and local administration to individual nuclei of the catecholaminergic brain system

, : Differences in the effects of 6 hydroxy dopamine on rat learning after ventricular and local administration to individual nuclei of the catecholaminergic brain system. Byulleten' Eksperimental'noi Biologii i Meditsiny 96(8): 6-8

Correlation of the effects obtained with different routes of 6-hydroxydopamine (6-OHDA) administration to the rat brain on the training showed that the drug injection of the lateral ventricles of the brain markedly interferes with the animals' learning both on food and painful reinforcement. Administration of 6-OHDA to the area as noradrenergic neurons accumulation (A6) is followed by the reduction of active avoidance behavior and facilitation of the training on food reinforcement. Local administration of 6-OHDA to the area of dopaminergic neuron accumulation (A9) decreases the reliability of the formed habits whatever the emotional sign of the reinforcing stimulant.

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