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Differences in the fine specificities of monoclonal (Class A) antibodies to human myeloid cells

, : Differences in the fine specificities of monoclonal (Class A) antibodies to human myeloid cells. Clinical and Experimental Immunology 60(1): 151-158

Among 13 monoclonal antibodies to human myelomonocytic cells, six could be assigned to a group designated Class A with the following properties: (a) they react almost exclusively with granulocytes among cells of the peripheral blood, (b) they resemble the previously described anti-granulocyte antibodies, VEP8 and VEP9, and the anti-mouse embryo, anti-SSEA-1, in their strong reactions with human meconium glycoproteins and ovarian cyst mucins of non-secretor type and (c) they recognize the carbohydrate antigen 3-fucosyl-N-acetyllactosamine (alpha 1----3fucosylated Type 2 blood group chains). The binding of these anti-myeloid antibodies is more strongly inhibited by lacto-N-fucopentaose III than by the trisaccharide-fucosyl-N-acetyllactosamine, in contrast to anti-SSEA-1 which is more strongly inhibited by the trisaccharide. These observations suggest that the myeloid Class A antibodies recognize additional determinants on the neolacto (Gal beta 1----4GlcNAc beta 1----3Gal beta 1----4) backbone of the pentasaccharide which occurs on the glycoproteins and glycolipids of myeloid cells. However, no two of the anti-myeloid antibodies were identical in their inhibition patterns with the glycoproteins and the two oligosaccharides. They also differed in their cellular reactivities, for example, the proportion of cells in the K-562 cell line reacting with each antibody ranged from 15-57%.

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Accession: 005151278

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Other references

Csanda E.; Papp M.I.; Tarczy M.; Takats A., 1990: Some possible histopathological correlates of dementia in parkinsonian patients. Battistin, L And F Gerstenbrand (Ed ) Neurology And Neurobiology, Vol 54 Aging Brain And Dementia: New Trends in Diagnosis And Therapy; Symposium, Padova, Italy, September 22-24, 1988 Xxvi+648p Wiley-Liss: New York, New York, Usa Illus 119-132

Izu, Leighton T.; Xie, Yuanfang; Sato, Daisuke; Bányász, Tamás; Chen-Izu, Ye, 2013: Ca2+ waves in the heart. Ca<sup loc="post">2<hsp sp="0.10"/>+</sup> waves were probably first observed in the early 1940s. Since then Ca<sup loc="post">2<hsp sp="0.10"/>+</sup> waves have captured...

Mogarkar K.M.; Khatoon S., 1979: Trematosphaeria chandrapurensis new species of fungus on abutilon indicum from maharashtra india. Marathwada University Journal of Sciences 18(11): 77-80

Fast, Vladimir G.; Kleber, Andre G., 1994: Conduction velocity and shape of action potential upstroke in a computer model of an anisotropic heart cell monolayer. Circulation 90(4 PART 2): I411

Raterron Paul; Chen Jiuhua; Li Li; Weidner Donald; Cordier Patrick, 2007: Pressure-induced slip-system transition in forsterite; single-crystal rheological properties at mantle pressure and temperature. Deformation experiments were carried out in a Deformation-DIA high-pressure apparatus (D-DIA) on oriented Mg (sub 2) SiO (sub 4) olivine (Fo100) single crystals, at pressure (P) ranging from 2.1 to 7.5 GPa, in the temperature (T) range 1373-1677 K...

Carroll, Rf, 1981: Improving the pit latrine Sanitation system. Water and waste engineering in Africa: proceedings edited by John Pickford and Susan Ball: 201

Calver James Lewis, 1952: Geology and location of lime sources in Florida. Pages 56-60 1952

Soo, R., 1967: Main characteristics of the evolution of embryophytes. Feddes Repert 76(1/2): 63-81

Bouissou, Mf, 1974: Establishment of dominance-submission relationships in domes tic cattle. I. Nature and evolution of social interactions. Annales de biologie animale biochimie biophysique: 4 (3) 383-410

Lukk A. A.; Yunga S. L., 1989: Fractals and strain-deformation conditions in the crust of the Garm region. Geologiya i Geofizika Tadzhikistana: ges 259-276. 1989.