EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Differences in the hepatic and renal extraction of insulin and glucagon in the dog: evidence for saturability of insulin metabolism






Acta Endocrinologica 102(3): 420-427

Differences in the hepatic and renal extraction of insulin and glucagon in the dog: evidence for saturability of insulin metabolism

The metabolism of exogenously infused porcine insulin and glucagon was assessed concurrently in normal fasted dogs under anesthesia. Hepatic and renal extraction of glucagon were 25.6 .+-. 2.3 and 43.7 .+-. 3.9%, respectively, and its metabolic clearance 16.5 .+-. 0.8 ml/kg per min. Hepatic and renal extraction accounted for 28.5 .+-. 4.2 and 28.7 .+-. 3.7% of total glucagon clearance, respectively. Insulin MCR [metabolic clearance rate] was 18.3 .+-. 1.5 ml/kg per min and its hepatic and renal extraction were 49.6 .+-. 3.4 and 41.7 .+-. 4.4% accounting for 51.9 .+-. 4.4 and 27.3 .+-. 3.9% of total insulin clearance, respectively. Neither total glucagon metabolic clearance nor its hepatic or renal components saturated even in the face of circulating glucagon levels extending into the pharmacologic range up to 14 ng/ml. In contrast, however, with increasing arterial concentrations of insulin, saturability of metabolism was apparent as evidenced by significant reductions in MCR and hepatic and renal extraction. This demonstration of saturability of hepatic extraction. This demonstration of saturability of hepatic insulin metabolism occurred at levels encountered in the portal vein after meals and is compatible with the concept that the hepatic capacity for extraction of this hormone may be an important site of control of the proportion of secreted insulin reaching the periphery. The metabolic handling of each hormone was shown to be independent of the other. Despite similarities in the interaction of insulin and glucagon with the target cell, there are important differences in the mechanisms of metabolism of these peptides at the major degradative sites.

(PDF same-day service: $19.90)

Accession: 005151304

PMID: 6338678

DOI: 10.1530/acta.0.1020420



Related references

Effects of age and sex on postprandial glucose metabolism: differences in glucose turnover, insulin secretion, insulin action, and hepatic insulin extraction. Diabetes 55(7): 2001-2014, 2006

Effects of stimulation of insulin and glucagon secretion on hepatic extraction of insulin and glucagon in the dog. Clinical Research 25(3): 498A, 1977

Renal extraction of endogenous/insulin, glucagon and gastrin during acute hepatic insufficiency in dogs. L'ateneo Parmense. Acta Bio-Medica 49(2): 243-244, 1978

Glucose ingestion in dogs alters the hepatic extraction of insulin. In vivo evidence for a relationship between biologic action and extraction of insulin. Journal of Clinical Investigation 69(3): 516-525, 1982

Insulin extraction by the isolated perfused rat liver. The effect of portal insulin mass inflow and the duration of infusion on hepatic extraction and elimination rate of insulin. Biomedica Biochimica Acta 43(6): 727-740, 1984

Insulin extraction by the isolated perfused rat liver influence of the portal insulin input and of the duration of infusion on the percentage of hepatic extraction and removal rate of insulin. Biomedica Biochimica Acta 43(6): 727-740, 1984

Adequately adapted insulin secretion and decreased hepatic insulin extraction cause elevated insulin concentrations in insulin resistant non-diabetic adrenal incidentaloma patients. Plos One 8(10): E77326-E77326, 2014

Turner's syndrome and carbohydrate metabolism. I. Impaired insulin secretion after tolbutamide and glucagon stimulation tests: evidence of insulin deficiency. American Journal of the Medical Sciences 277(2): 145-152, 1979

The effect of exogenous insulin glucagon and insulin glucagon administration on the liver function and hepatic glycogen status in rats with eck fistula. Journal of Catholic Medical College 44(1): 127-138, 1991

Effect of a long term very low calorie diet on glucose/insulin metabolism in obesity. Influence of fat distribution on hepatic insulin extraction. International Journal of Obesity 13 Suppl 2: 47-49, 1989