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Differences in the immune and non-immune interaction of peritoneal macrophages from the Biozzi high and low responder lines of mice with sheep red blood cells

, : Differences in the immune and non-immune interaction of peritoneal macrophages from the Biozzi high and low responder lines of mice with sheep red blood cells. Journal of the Reticuloendothelial Society 21(5): 331-342

The immune and non-immune interactions of peritoneal macrophages from high (Ab/H) and low (Ab/L) responder mice with sheep red blood cells (SRBC) were studied in vitro by separately investigating the attachment and interiorization phases of phagocytosis. Ab/L macrophages were hyperactive with regard to the attachment and ingestion of 51Cr-labeled SRBC(51CrSRBC) sensitized with rabbit anti-SRBC serum or mouse anti-SRBC Ig[immunoglobulin]M. Ab/H macrophages were more active in the non-immune attachment of glutaraldehyde-treated SRBC (G-SRBC) labeled with 51Cr (51CrG-SRBC). Interiorization of G-SRBC by Ab/H macrophages was faster under conditions which favor phagocytosis. Anti-SRBC serum stimulated the uptake of 51CrG-SRBC by Ab/L but not by Ab/H macrophages. In the presence of anti-SRBC serum the enhanced uptake of SRBC and G-SRBC by Ab/L macrophages was accompanied by stimulation of direct glucose-C-1 oxidation. This phenomenon could not be explained by any differences in glucose-6-phosphate dehydrogenase and 6-phospho-gluconate dehydrogenase activities between Ab/H and Ab/L macrophages. Macrophages from high and low responder mice apparently differ in their display of Fc receptors and other surface binding sites for modified SRBC. These distinct membrane sites, which seem to be important mediators in the regulation of Ab production, are apparently determined by genes that segregated in the 2 mouse lines during selection.

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