EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Differences in the in vivo and in vitro effects of the carbamate insecticide, carbaryl on rat hepatic monooxygenases


, : Differences in the in vivo and in vitro effects of the carbamate insecticide, carbaryl on rat hepatic monooxygenases. Drug and Chemical Toxicology 9(3-4): 253-273

The effects of one of the most widely used insecticides, carbaryl, on the hepatic cytochrome P-450-dependent monooxygenases were determined. Addition of carbaryl to liver microsomes from untreated or phenobarbital (PB)-pretreated rats resulted in a weak Type I binding spectrum. A much stronger spectral Type I interaction was observed when microsomes from 3-methylcholanthrene(3-MC)-treated rats were used. In vitro, carbaryl caused marked inhibition of ethylmorphine and benzphetamine N-demethylases, benzo(a)pyrene hydroxylase, 7-ethoxycoumarin and 7-ethoxyresorufin O-deethylases in liver microsomes. Kinetic studies demonstrated that carbaryl was a competitive inhibitor of ethylmorphine N-demethylase activity. Daily administration of carbaryl for 4 days by gavage or intraperitoneally resulted in no significant alterations in hepatic cytochrome P-450 levels, ethylmorphine N-demethylase or benzo(a)pyrene hydroxylase activities. The lack of effect of carbaryl in vivo may be due to the rapid metabolism of the insecticide, such that the insecticide may not be present in the liver endoplasmic reticulum to cause the inhibitory effects observed in vitro.

(PDF same-day service: $19.90)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 005151316

PMID: 3102203

DOI: 10.3109/01480548608998279

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Anonymous., 1987: A list of literature on Radiolaria 1977-1987. Plankton Newsletter, 6: 8-20

Neall Tim; Green David I., 2001: Raspite from Carrock Mine, Caldbeck Fells, Cumbria, England; a first British occurrence. Journal of the Russell Society 7, Part 2: 91

Tillmanns, T.D.; Falkner, C.A.; Engle, D.B.; Wan, J.Y.; Mannel, R.S.; Walker, J.L.; Johnson, G.A.; McMeekin, D.Scott.; Zuna, R.; Gold, M.A., 2005: Preoperative predictors of positive margins after loop electrosurgical excisional procedure-Cone. Objective. A LEEP-Cone may not be necessary for all patients with traditional cone indications. This study defines populations where a single pass technique with the LEEP is appropriate.Methods. We retrospectively reviewed patients undergoing LEEP...

Okushima, Yuichi.; Sato, Masataka., 2000: A record of Wittmercantharis curtata Coleoptera, Cantharidae from Hokkaido, Japan. Elytra. Nov 15; 282: 245-246

Oommen, J.; Kraus, A.C.; Fisher, R.S., 2007: Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold. Introduction: We investigated efficacy of prolonged intraventricular gabapentin (GBP) infusion in the rat flurothyl epilepsy model. Methods: Sprague-Dawley rats, under anesthesia, were implanted with bilateral Alzet model 2001 osmotic pumps. The...

Witte D.P.; Harris R.E.; Jenski L.J.; Lampkin B.C., 1986: Megakaryoblastic leukemia in an infant establishment of a megakaryocytic tumor cell line in athymic nude mice. A 17-month-old infant with clinical and pathologic features of acute megakaryoblastic leukemia and myelofibrosis developed soft tissue metastases. Tissue from an orbital metastasis was biopsied and transplanted into a nude mouse. Histologically th...

Boast, Cw, 1977: Shape of a streamline water table near inflow and outflow boundaries. Water resources research: 13 (2) 325-328

Newman, M. D., 1987: Grain marketing in Senegal's peanut basin: 1984/85 situation and issues. This study is based on the preliminary findings of surveys and interviews conducted by the Macro Economic Analysis Bureau (BAME) of Senegal's Agricultural Research Institute (ISRA). It briefly describes the current grain marketing situation,...

Ramsay J.; Taylor D., 1980: Congenital crocodile tears a key to the etiology of duanes syndrome. Copious lacrimation during eating in some patients with Duane's syndrome from afterbirth implies dysgenesis or a lesion in the vicinity of the abducens nucleus in the pons.

Sullivan, C.J.; McKendrick, K.; Sacks, S.; Banks, S., 2007: Modified therapeutic community treatment for offenders with MICA disorders: substance use outcomes. Correctional systems nationwide have increasingly turned to therapeutic community (TC) programs for the treatment of addiction in prisons. TC treatment, with modifications, has shown considerable promise in treating offenders who have co-occurring...