EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Differences in the inhibitory effects of normorphine and opioid peptides on the responses of the vasa deferentia of 2 strains of mice


, : Differences in the inhibitory effects of normorphine and opioid peptides on the responses of the vasa deferentia of 2 strains of mice. European Journal of Pharmacology 47(2): 249-250

The opioid peptidergic system is of considerable complexity and several agonists are matched by multiple receptors. Further proof is given by making use of differences observed between different strains of mice. Five compounds of different binding characteristics were used to test the sensitivity of the vasa deferentia to endogenous opioid peptides and morphine. The first 3 compounds were the natural enkephalins and the analog Tyr-D-Ala-Gly-Phe-Met, the 4th .beta.-endorphin and the last normorphine. Their inhibitory potencies on the binding of [3H]-naltrexone and [3H]-leucine-enkephalin to homogenates of guinea pig brains were also determined. The results are the 1st evidence for a genetic variation in the ratio of the .mu.- and .delta.[opioid]-receptors in the mouse vas deferens. There is no significant difference in the number of sensitivity of .delta.-receptors which interact preferentially with the endogenous opioid peptides, the enkephalins and endorphins. The difference between the strains is in the sensitivity of their .mu.-receptors, mainly interacting with opioid alkaloid morphine and its surrogates. [Addictive drug seeking behavior is discussed.].

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 005151332

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Harp, J.A.; Stabel, J.R.; Pesch, B.A.; Goff, J.P., 2004: Expression of adhesion molecules on milk and blood lymphocytes from periparturient dairy cattle with Johne's disease. Twelve dairy cows infected with Mycobacterium avium subsp. paratuberculosis were monitored for lymphocyte subsets and expression of adhesion molecules on cells in blood and milk at parturition and at intervals up to 21 days post-partum. Using fluo...

Bubenchykova, V.M.; Popova, T.P.; Lytvynenko, V.I., 1992: Flavonoids from dandelion. Farmatsevtychnyi Zhurnal (Kiev) 0(1): 87

Kato, L., 1977: The janus-face of Mycobacterium leprae: characteristics of in vitro grown M. leprae are not predictable. International Journal of Leprosy and Other Mycobacterial Diseases 45(2): 175-185

Hené, R.J.; Velthuis, P.; van de Wiel, A.; Kater, L.; Mees, E.J., 1986: Utility of skin biopsy in the diagnosis of IgA nephropathy. American Journal of Kidney Diseases 7(5): 442-442

Liphardt, J.; Dumont, S.; Smith, S.B.; Tinoco, I.; Bustamante, C., 2002: Equilibrium information from nonequilibrium measurements in an experimental test of Jarzynski's equality. Recent advances in statistical mechanical theory can be used to solve a fundamental problem in experimental thermodynamics. In 1997, Jarzynski proved an equality relating the irreversible work to the equilibrium free energy difference, DG. This...

Rekow, E.D.; Worms, F.W.; Erdman, A.G.; Speidel, T.M., 1985: Treatment-induced errors in occlusion following orthognathic surgery. Posttreatment occlusion following orthognathic surgery is often different from that predicted in the treatment plan. Differences between intended and actual occlusion may be treatment-induced occlusal errors caused by mismatches between the center...

Hogan, A.J., 1986: Evaluating reliability. A cost-effectiveness approach. This study derives the economic costs of misclassification in nursing home patient classification systems. These costs are then used as weights to estimate the reliability of a functional assessment instrument applied to 290 Veterans Administratio...

Farhat, F.; Kattan, J.; Culine, S.; Bekradda, M.; Droz, J.P., 1994: 5-Fluorouracil, Adriamycin and cisplatinum (FAP regimen) efficacy in metastatic adenoid cystic carcinoma: A case report and review of the literature. We report the case of a 43 year-old woman who was submitted to a complete surgical resection of an Adenoid Cystic Carcinoma (A CC) of the submandibular salivary gland which was associated with diffuse lung metastases. Combination chemotherapy with...

Smith, D.P.; Thrash, J.Cameron.; Nicora, C.D.; Lipton, M.S.; Burnum-Johnson, K.E.; Carini, P.; Smith, R.D.; Giovannoni, S.J., 2014: Proteomic and transcriptomic analyses of "Candidatus Pelagibacter ubique" describe the first PII-independent response to nitrogen limitation in a free-living Alphaproteobacterium. Mbio 4(6): E00133-12

Jeon, M.Kyeong.; Kang, S.Joo.; Sun, H., 2013: Platysma flap with z-plasty for correction of post-thyroidectomy swallowing deformity. Recently, the number of thyroid surgery cases has been increasing; consequently, the number of patients who visit plastic surgery departments with a chief complaint of swallowing deformity has also increased. We performed a scar correction techniq...