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Differences in the inhibitory effects of normorphine and opioid peptides on the responses of the vasa deferentia of 2 strains of mice

, : Differences in the inhibitory effects of normorphine and opioid peptides on the responses of the vasa deferentia of 2 strains of mice. European Journal of Pharmacology 47(2): 249-250

The opioid peptidergic system is of considerable complexity and several agonists are matched by multiple receptors. Further proof is given by making use of differences observed between different strains of mice. Five compounds of different binding characteristics were used to test the sensitivity of the vasa deferentia to endogenous opioid peptides and morphine. The first 3 compounds were the natural enkephalins and the analog Tyr-D-Ala-Gly-Phe-Met, the 4th .beta.-endorphin and the last normorphine. Their inhibitory potencies on the binding of [3H]-naltrexone and [3H]-leucine-enkephalin to homogenates of guinea pig brains were also determined. The results are the 1st evidence for a genetic variation in the ratio of the .mu.- and .delta.[opioid]-receptors in the mouse vas deferens. There is no significant difference in the number of sensitivity of .delta.-receptors which interact preferentially with the endogenous opioid peptides, the enkephalins and endorphins. The difference between the strains is in the sensitivity of their .mu.-receptors, mainly interacting with opioid alkaloid morphine and its surrogates. [Addictive drug seeking behavior is discussed.].

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