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Differences in the interactions between gamma amino butyric acid and benzodiazepine binding sites


Neuroscience Letters 33(2): 173-178
Differences in the interactions between gamma amino butyric acid and benzodiazepine binding sites
Enhancement of GABA binding to rat brain membranes by diazepam was halved following freezing and almost abolished by high frequency homogenization and detergent extraction. Stimulation of diazepam binding by GABA was not reduced by these procedures. GABA enhancement of benzodiazepine binding appears to be a relatively robust phenomenon, whereas diazepam enhancement of GABA binding is quite sensitive to membrane perturbations and may involve endogenous modulators.


Accession: 005151340



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