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Differences in the interactions between gamma amino butyric acid and benzodiazepine binding sites


, : Differences in the interactions between gamma amino butyric acid and benzodiazepine binding sites. Neuroscience Letters 33(2): 173-178

Enhancement of GABA binding to rat brain membranes by diazepam was halved following freezing and almost abolished by high frequency homogenization and detergent extraction. Stimulation of diazepam binding by GABA was not reduced by these procedures. GABA enhancement of benzodiazepine binding appears to be a relatively robust phenomenon, whereas diazepam enhancement of GABA binding is quite sensitive to membrane perturbations and may involve endogenous modulators.

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Other references

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Netea, Mihai G.; Van Der Meer, Jos W. M.; Fenton, Matthew J.; Kullberg, Bart Jan, 2002: Pathogenic fungi induce proinflammatory cytokines and chemokines through different Toll-like receptor Mediated pathways. Journal of Interferon & Cytokine Research 22(Supplement 1): S-89

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