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Differences in the major histo compatibility complex restricted self recognition repertoire of intra thymic and extrathymic cyto toxic t lymphocyte precursors

, : Differences in the major histo compatibility complex restricted self recognition repertoire of intra thymic and extrathymic cyto toxic t lymphocyte precursors. Journal of Immunology 130(3): 1027-1032

The MHC [major histocompatibility complex] specificity of TNP[trinitrophenyl]-specific pCTL [precursor cytotoxic T lymphocyte] from the [mouse] thymus and spleen of F1 .fwdarw. parent chimeras was evaluated. In the presence of exogenously added helper factor IL 2 [interleukin 2] thymic pCTL were restricted to recognizing TNP only in association with host MHC determinants, whereas splenic pCTL recognized TNP in association with either host or donor MHC determinants. The spleens of F1 .fwdarw. parent chimeras contain a pCTL repertoire that is not present intrathymically. Data are presented which suggest that such pCTL did differentiate into functional competence in the chimeric host. The results are consistent with extrathymic differentiation as the mechanism by which such nonthymically restricted pCTL may have developed.

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