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Differences in the maturation of the immune response of a negative and a positive rabbits good and poor responders respectively for the a antigen


, : Differences in the maturation of the immune response of a negative and a positive rabbits good and poor responders respectively for the a antigen. Immunology 33(1): 91-100

The amount, avidity and specificity of anti-A antibodies produced by rabbits having the A substance in their secretions (A+) and rabbits lacking this antigen (A-) were studied with a series of antigens chemically related to the A substance. A- and A+ rabbits produced specific anti-A antibodies, but the amount, maturation of avidity and specificity of these antibodies was completely different. The difference between the immune response of A+ and A- animals may not be based on a genetically determined inability of A+ rabbits to recognize the self antigen, but rather on differences in the regulatory mechanism(s) controlling the maturation process of the anti-A response.

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