EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Differences in the mechanism of nadph supported and cumene hydro per oxide supported reactions of cytochrome p 450


Archives of Biochemistry and Biophysics 200(1): 186-195
Differences in the mechanism of nadph supported and cumene hydro per oxide supported reactions of cytochrome p 450
The mechanism of NADPH- and cumene hydroperoxide-supported hydroxylation of benzo(a)pyrene as catalyzed by rat liver microsomes was studied using high pressure liquid chromatography, fluorescence and spectrophotometric methods. Repetitive scan difference spectral analysis clearly demonstrated that during the steady state of these reactions, different products were formed.

(PDF 0-2 workdays service: $29.90)

Accession: 005151385



Related references

Comparative studies on the cumene hydro per oxide supported and nadph supported n oxidation of 4 chloro aniline by cytochrome p 450 ec 1.14.14.1. Biochemical Journal 212(3): 539-548, 1983

Differences in the mechanism of NADPH- and cumene hydroperoxide-supported reactions of cytochrome P-450. Archives of Biochemistry and Biophysics 200(1): 186-195, 1980

Propranolol hydroxylation and N-desisopropylation by cytochrome P4502D6: studies using the yeast-expressed enzyme and NADPH/O2 and cumene hydroperoxide-supported reactions. Drug Metabolism and Disposition: the Biological Fate of Chemicals 24(1): 112-118, 1996

Cumene hydroperoxide supported oxidation of ethanol by microsomes from chronic ethanol treated rats differences from an nadph supported system. IRCS (International Research Communications System) Medical Science 13(1): 66-67, 1985

Comparative studies on the cumene hydroperoxide- and NADPH-supported N-oxidation of 4-chloroaniline by cytochrome P-450. Biochemical Journal 212(3): 539-547, 1983

Esr studies on the cumene hydro per oxide supported oxidation of aminopyrine by catalase. Chemical & Pharmaceutical Bulletin (Tokyo) 28(7): 2077-2082, 1980

Acetone enhancement of cumene hydro per oxide supported microsomal aniline hydroxylation. Life Sciences 25(12): 1085-1090, 1979

Kinetic mechanism of the cumene hydro per oxide and p methyl cumene hydro per oxide dependent hydroxylation of substituted toluenes catalyzed by p 450l m 2. Federation Proceedings 39(6): ABSTRACT 2365, 1980

Cumene hydroperoxide-supported demethylation reactions catalyzed by cytochrome P450 2B4 lacking the NH2-terminal sequence. Biochemical and Biophysical Research Communications 258(1): 32-38, 1999

Cumene hydroperoxide-supported demethylation reactions catalyzed by cytochrome P450 2B4 lacking the NH2-terminal region. FASEB Journal 13(7): A1345, April 23, 1999