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Differences in the mechanism of the development of hbsag positive and hbsag negative forms of chronic active hepatitis


, : Differences in the mechanism of the development of hbsag positive and hbsag negative forms of chronic active hepatitis. Klinicheskaya Meditsina (Moscow) 64(11): 73-78

A comparative evaluation was carried out of the quantitative indices and functional activity of cellular and humoral immunity, as well as of the features of the histological and electron microscopic study of liver biopsy specimens of 30 hepatitis patients. T-suppressor cells predominated in the peripheral blood of patients with the HbsAg-positive form of hepatitis. Accumulations of aggressive lymphocytes were found in necrotic foci. Apparently these lymphocytes are T-killers. A pronounced decrease in the amount and functional activity of T-suppressors was observed in patients with the HBsAg-negative form of chronic active hepatitis [CAH]. In HBsAg-positive CAH, the damage to hepatocytes is determined by T-killers and macrophages, but in HBsAg-negative CAH, lymphocytes may be responsible for antibody-dependent cytotoxicity.

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