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Differences in the mechanisms of cell cell and cell substrate adhesion revealed in a human retino blastoma cell line

Cell Structure & Function 5(2): 183-190

Differences in the mechanisms of cell cell and cell substrate adhesion revealed in a human retino blastoma cell line

Cellular adhesive properties of Y79 cells established from a human retinoblastoma were investigated. Y79 cells were characterized by their mutual adhesiveness in forming clusters and by the complete inability to attach to a noncellular culture substrate. The cell-cell adhesion of Y79 cells depends on 2 mechanisms. One is Ca2+-dependent and the other Ca2+-independent, as in the case of [Chinese hamster lung] V79 cells which adhere mutually and to the culture substrate. That Y79 cells share common adhesive sites for cell-cell adhesion with V79 cells was suggested from the results of the heterotypic aggregation of these 2 cell types. Y79 cells attached themselves to a monolayer of V79 cells, but not to the substrate of the plastic dishes, when the medium contained serum. The mechanisms that operate for cell-substrate adhesion differs qualitatively from the mechanisms for cell-cell adhesion.

Accession: 005151390

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