EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Differences in the mechanisms of cell cell and cell substrate adhesion revealed in a human retino blastoma cell line


, : Differences in the mechanisms of cell cell and cell substrate adhesion revealed in a human retino blastoma cell line. Cell Structure & Function 5(2): 183-190

Cellular adhesive properties of Y79 cells established from a human retinoblastoma were investigated. Y79 cells were characterized by their mutual adhesiveness in forming clusters and by the complete inability to attach to a noncellular culture substrate. The cell-cell adhesion of Y79 cells depends on 2 mechanisms. One is Ca2+-dependent and the other Ca2+-independent, as in the case of [Chinese hamster lung] V79 cells which adhere mutually and to the culture substrate. That Y79 cells share common adhesive sites for cell-cell adhesion with V79 cells was suggested from the results of the heterotypic aggregation of these 2 cell types. Y79 cells attached themselves to a monolayer of V79 cells, but not to the substrate of the plastic dishes, when the medium contained serum. The mechanisms that operate for cell-substrate adhesion differs qualitatively from the mechanisms for cell-cell adhesion.


Accession: 005151390

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Ueda K.; Takeichi M.; Okada T.S., 1979: On the relation between cell cell adhesion and cell substrate adhesion mechanisms studies using human retino blastoma cell line y 79 minus. Cell Structure & Function 4(4): 346

Rubin N.A.; Gregerson D.S.; Reid T.W., 1980: Retino blastoma derived growth factor a mitogenic factor secreted by an established human retino blastoma cell line. Investigative Ophthalmology & Visual Science O(SUPPL): 96

Aoyama, H.; Okada, T.S., 1977: Mechanisms of cell to cell and cell to substrate adhesion of human epithelial chang conjunctiva cells. The adhesive property was studied of Chang conjunctiva cells of human epithelial line. Cells dissociated with only EDTA aggregated in Ca2+-free and Mg2+-free conditions; trypsin-dissociated cells did not aggregate under the same conditions. Cells...

Mcfall R.C.; Sery T.W.; Makadon M., 1976: Characterization of a new continuous cell line from a human retino blastoma. In Vitro (Rockville) 12(4): 327

Brown J.W.; Chen M.G., 1978: Radiation response of an established human retino blastoma cell line in vitro. Radiation Research 74(3): 497

Adams, C.L.; Chen, Y.T.i; Smith, S.J.; Nelson, W.J.mes, 1998: Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein. Cadherin-mediated adhesion initiates cell reorganization into tissues, but the mechanisms and dynamics of such adhesion are poorly understood. Using time-lapse imaging and photobleach recovery analyses of a fully functional E-cadherin/GFP fusion p...

Adams, C.L.; Chen, Y.T.; Smith, S.J.; Nelson, W.J., 1998: Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein. Cadherin-mediated adhesion initiates cell reorganization into tissues, but the mechanisms and dynamics of such adhesion are poorly understood. Using time-lapse imaging and photobleach recovery analyses of a fully functional E-cadherin/GFP fusion p...

Cowell, H.E.; Garrod, D.R., 1999: Activation of protein kinase C modulates cell-cell and cell-substratum adhesion of a human colorectal carcinoma cell line and restores 'normal' epithelial morphology. Abnormal cell adhesion is an important contributing factor in invasion and metastasis. Here, we show that morphologically 'normal' cell-cell and cell-substratum adhesion can be restored to a poorly differentiated carcinoma cell line by a...

Cowell, H.E.; Garrod, D.R., 1999: Activation of protein kinase C modulates cell-cell and cell-substratum adhesion of a human colorectal carcinoma cell line and restores 'normal' epithelial morphology. Abnormal cell adhesion is an important contributing factor in invasion and metastasis. Here, we show that morphologically 'normal' cell-cell and cell-substratum adhesion can be restored to a poorly differentiated carcinoma cell line by a...

Atlas, E.; Kerr, P.; Savas, B.; Cole, S.P.C.; Pross, H., 1992: Expression of cell adhesion molecules associated with differences in NK and LAK cell sensitivity of the SCLC cell line H69 and a multidrug-resistant variant H69AR. Natural Immunity 11(5): 274