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Differences in the methylation of brain histamine in vivo between audiogenic seizure sensitive and seizure resistant deer mice peromyscus spp


Life Sciences 28(25): 2805-2810
Differences in the methylation of brain histamine in vivo between audiogenic seizure sensitive and seizure resistant deer mice peromyscus spp
The catabolism of [3H] histamine (HA) after intraventricular (i.vt.) administration, was investigated in brains of the audiogenic seizure susceptible (SS) and resistant (SR) deermouse Peromyscus. Brains of SS mice had lower endogenous HA levels and contained less [3H]-HA 20, 60 and 300 s after i.vt. [3H]-HA than did brains of SR deermice. Brain [3H] methylhistamine (MeHA) levels and the resulting MeHA conversion index were increased in the SS animals 20 s after [3H]-HA, while later, at 60 and 300 s, these parameters were decreased. There were no SS-SR differences in the levels of brain [3H] methylimidazoleacetic acid. SS deermice apparently catabolize exogenous HA, at least initially, more rapidly than their SR counterparts, confirming a like result noted immediately prior to seizure activity elicited by the administration of L-methionine-dl-sulfoximine in Mus.


Accession: 005151402



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