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Differences in the migration of b lymphocytes and t lymphocytes organ selective localization in vivo and the role of lymphocyte endothelial cell recognition


, : Differences in the migration of b lymphocytes and t lymphocytes organ selective localization in vivo and the role of lymphocyte endothelial cell recognition. Journal of Immunology 128(2): 844-851

The migration of mouse B and T lymphocytes was studied by using short-term in vivo homing studies and an in vitro assay of lymphocyte binding to specialized lymphoid organ venules [post-capillary, high endothelial venules (HEV)] in frozen sections of lymph nodes and Peyer's patches. The homing characteristics of B and T cell populations are largely independent of their organ of origin. B cells from any source distribute preferentially to Peyer's patches; T cells home preferentially to peripheral lymph nodes. This organ specificity of migration appears to be determined at the site of lymphocyte exit from the blood by selective recognition of organ-specific determinants on the endothelial cells of HEV. The in vivo tendency of B cells to migrate preferentially to the spleen and of T cells to localize better in lymph nodes is confirmed. In a hypothetical situation in which an equal number of B and T lymphocytes localized in peripheral lymph nodes (or bound in vitro to peripheral node HEV), there would be .apprx. 2.5 B cells/T cell in the mesenteric node, 4-6 B cells/T cell in Peyer's patches and 7-9 B cells/T cell in the spleen. Comparison of these homing preferences with the distribution of B and T lymphocyte populations in situ suggests that selective lymphocyte migration may help determine the proportions of functionally distinct lymphocyte classes in particular lymphoid organs or sites of chronic inflammation and may serve to influence the character of local immune responses.

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