EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Differences in the migration of b lymphocytes and t lymphocytes organ selective localization in vivo and the role of lymphocyte endothelial cell recognition






Journal of Immunology 128(2): 844-851

Differences in the migration of b lymphocytes and t lymphocytes organ selective localization in vivo and the role of lymphocyte endothelial cell recognition

The migration of mouse B and T lymphocytes was studied by using short-term in vivo homing studies and an in vitro assay of lymphocyte binding to specialized lymphoid organ venules [post-capillary, high endothelial venules (HEV)] in frozen sections of lymph nodes and Peyer's patches. The homing characteristics of B and T cell populations are largely independent of their organ of origin. B cells from any source distribute preferentially to Peyer's patches; T cells home preferentially to peripheral lymph nodes. This organ specificity of migration appears to be determined at the site of lymphocyte exit from the blood by selective recognition of organ-specific determinants on the endothelial cells of HEV. The in vivo tendency of B cells to migrate preferentially to the spleen and of T cells to localize better in lymph nodes is confirmed. In a hypothetical situation in which an equal number of B and T lymphocytes localized in peripheral lymph nodes (or bound in vitro to peripheral node HEV), there would be .apprx. 2.5 B cells/T cell in the mesenteric node, 4-6 B cells/T cell in Peyer's patches and 7-9 B cells/T cell in the spleen. Comparison of these homing preferences with the distribution of B and T lymphocyte populations in situ suggests that selective lymphocyte migration may help determine the proportions of functionally distinct lymphocyte classes in particular lymphoid organs or sites of chronic inflammation and may serve to influence the character of local immune responses.


Accession: 005151406



Related references

Stevens, S.K.; Weissman, I.L.; Butcher, E.C., 1982: Differences in the migration of B and T lymphocytes: organ-selective localization in vivo and the role of lymphocyte-endothelial cell recognition. The migration of B and T lymphocytes in the mouse has been studied by using 1) short-term in vivo homing studies, and 2) an in vitro assay of lymphocyte binding to specialized lymphoid organ venules (post-capillary, high endothelial venules (HEV))...

Butcher, E.C.; Kraal, G.; Stevens, S.K.; Weissman, I.L., 1982: Selective migration of murine lymphocytes and lymphoblast populations and the role of endothelial cell recognition. Advances in Experimental Medicine and Biology 149: 199-206

W.N.; Jalkanen S.; Hsu M.; Smith S.; Butcher E., 1985: Organ specific lymphocyte endothelial cell recognition mechanisms expressed by human neoplastic lymphocytes. Federation Proceedings 44(4): 1261

Abernethy, N.J.; Hay, J.B.; Kimpton, W.G.; Washington, E.A.; Cahill, R.N., 1990: Non-random recirculation of small, CD4+ and CD8+ T lymphocytes in sheep: evidence for lymphocyte subset-specific lymphocyte- endothelial cell recognition. The migratory properties of small, CD4+ and CD8+ T lymphocyte subsets have been examined in sheep under physiological conditions. Lymphocytes obtained free-floating in lymph were directly labeled with fluorochrome in vitro and returned to the bloo...

Wilson, E.; Jutila, M.A., 1997: Generation of a supernatant fluid by stimulated lymphocytes that causes selective migration of lymphocytes through endothelial monolayers. Journal of Allergy & Clinical Immunology 99(1 PART 2): S318

Butcher E.C.; Stevens S.K.; Weissman I.L., 1982: Recognition of organ specific endothelial cell determinants by b and t lymphocytes. Journal of Supramolecular Structure & Cellular Biochemistry (SUPPL 5): 288

Butcher, E.C.; Scollay, R.G.; Weissman, I.L., 1980: Organ specificity of lymphocyte migration: mediation by highly selective lymphocyte interaction with organ-specific determinants on high endothelial venules. Evidence is presented that the organ specificity of lymphocyte migration is determined by selective interaction of lymphocytes with specialized endothelial cells. Mouse Peyer's patch and lymph node lymphocytes bind preferentially to high endo...

Abernethy N.J.; Hay J.B.; Kimpton W.G.; Washington E.A.; Cahill R.N.P., 1990: Non random recirculation of small cd4 positive and cd8 positive t lymphocytes in sheep evidence for lymphocyte subset specific lymphocyte endothelial cell recognition. The migratory properties of small, CD4+ and CD8+ T lymphocyte subsets have been examined in sheep under physiological conditions. Lymphocytes obtained free-floating in lymph were directly labeled with fluorochrome in vitro and returned to the bloo...

Cook Mills J.M.; Feldbush T.L., 1992: High endothelial venule hev cell lines bind lymphocytes and promote lymphocytes migration. FASEB Journal 6(4): A1145

Abernethy, N.J.; Hay, J.B.; Kimpton, W.G.; Washington, E.; Cahill, R.N., 1991: Lymphocyte subset-specific and tissue-specific lymphocyte-endothelial cell recognition mechanisms independently direct the recirculation of lymphocytes from blood to lymph in sheep. Tissue-specific and lymphocyte subset-specific lymphocyte recirculation patterns have been analysed simultaneously. Lymphocytes obtained from one lymph compartment were directly labelled with fluorochrome in vitro and returned to the blood of the...