EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Differences in the migration of b lymphocytes and t lymphocytes organ selective localization in vivo and the role of lymphocyte endothelial cell recognition






Journal of Immunology 128(2): 844-851

Differences in the migration of b lymphocytes and t lymphocytes organ selective localization in vivo and the role of lymphocyte endothelial cell recognition

The migration of mouse B and T lymphocytes was studied by using short-term in vivo homing studies and an in vitro assay of lymphocyte binding to specialized lymphoid organ venules [post-capillary, high endothelial venules (HEV)] in frozen sections of lymph nodes and Peyer's patches. The homing characteristics of B and T cell populations are largely independent of their organ of origin. B cells from any source distribute preferentially to Peyer's patches; T cells home preferentially to peripheral lymph nodes. This organ specificity of migration appears to be determined at the site of lymphocyte exit from the blood by selective recognition of organ-specific determinants on the endothelial cells of HEV. The in vivo tendency of B cells to migrate preferentially to the spleen and of T cells to localize better in lymph nodes is confirmed. In a hypothetical situation in which an equal number of B and T lymphocytes localized in peripheral lymph nodes (or bound in vitro to peripheral node HEV), there would be .apprx. 2.5 B cells/T cell in the mesenteric node, 4-6 B cells/T cell in Peyer's patches and 7-9 B cells/T cell in the spleen. Comparison of these homing preferences with the distribution of B and T lymphocyte populations in situ suggests that selective lymphocyte migration may help determine the proportions of functionally distinct lymphocyte classes in particular lymphoid organs or sites of chronic inflammation and may serve to influence the character of local immune responses.

(PDF 0-2 workdays service: $29.90)

Accession: 005151406



Related references

Differences in the migration of B and T lymphocytes: organ-selective localization in vivo and the role of lymphocyte-endothelial cell recognition. Journal of Immunology 128(2): 844-851, 1982

Selective migration of murine lymphocytes and lymphoblast populations and the role of endothelial cell recognition. Advances in Experimental Medicine and Biology 149: 199-206, 1982

Organ specific lymphocyte endothelial cell recognition mechanisms expressed by human neoplastic lymphocytes. Federation Proceedings 44(4): 1261, 1985

Non-random recirculation of small, CD4+ and CD8+ T lymphocytes in sheep: evidence for lymphocyte subset-specific lymphocyte- endothelial cell recognition. International Immunology 2(3): 231-238, 1990

Generation of a supernatant fluid by stimulated lymphocytes that causes selective migration of lymphocytes through endothelial monolayers. Journal of Allergy & Clinical Immunology 99(1 PART 2): S318, 1997

Recognition of organ specific endothelial cell determinants by b and t lymphocytes. Journal of Supramolecular Structure & Cellular Biochemistry (SUPPL 5): 288, 1982

Organ specificity of lymphocyte migration: mediation by highly selective lymphocyte interaction with organ-specific determinants on high endothelial venules. European Journal of Immunology 10(7): 556-561, 1980

Non random recirculation of small cd4 positive and cd8 positive t lymphocytes in sheep evidence for lymphocyte subset specific lymphocyte endothelial cell recognition. International Immunology 2(3): 231-238, 1990

High endothelial venule hev cell lines bind lymphocytes and promote lymphocytes migration. FASEB Journal 6(4): A1145, 1992

Lymphocyte subset-specific and tissue-specific lymphocyte-endothelial cell recognition mechanisms independently direct the recirculation of lymphocytes from blood to lymph in sheep. Immunology 72(2): 239-245, 1991