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Differences in the mode of exudative reaction between early phase and late phase of carrageenan induced inflammation in rats


, : Differences in the mode of exudative reaction between early phase and late phase of carrageenan induced inflammation in rats. European Journal of Pharmacology 36(1): 7-14

Differences in the mode of vascular permeability change induced by stimulants such as chemical mediators between the early phase and the late phase of the carrageenin-induced granulomatous inflammation were investigated using 131I-human serum albumin. In the early pregranulomatous inflammation phase, histamine injection into the inflammation locus markedly elevated local vascular permeability, while prostaglandins E1 and E2 showed no effect. In the late phase of the inflammation, where permanent granuloma tissue had been formed, prostaglandins E1 and E2 significantly enhanced the local vascular permeability, while histamine was inert.

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