EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Differences in the pregnancy terminating effectiveness of an lhrh analog by sub cutaneous vaginal rectal and nasal routes in rats


, : Differences in the pregnancy terminating effectiveness of an lhrh analog by sub cutaneous vaginal rectal and nasal routes in rats. Endocrinologia Japonica 29(4): 415-422

A long-acting analog of LHRH, des-Gly10-[D-Leu6]-LHRH-ethylamide (TAP-144), was administered once or twice on day 9 of pregnancy by s.c. vaginal, rectal and nasal routes to rats; the pregnancy-terminating effectiveness of these routes was determined on day 14. When rats were given a single dose of TAP-144, the ED50 value was 1.2 .mu.g/100 g body wt by the vaginal route, the effectiveness being 752 and 1221 times higher than those by the s.c. and rectal routes, respectively. Nasal administration was not effective in terminating pregnancy even at a high dose of 2000 .mu.g/100 g body wt. The addition of a surfactant (BL-9) did not increase the effectiveness by the rectal route. When TAP-144 was administered twice a day, the effectiveness was markedly increased by every route. The ED50 values were 0.32 .mu.g/100 g body wt per time by the s.c. route, which was comparable to that of the vaginal route, 14.2 .mu.g of the rectal route and 84.6 .mu.g of the nasal route. The addition of the surfactant increased the effectiveness 26 times by the nasal route but not by the rectal route. The pregnancy-terminating effect of TAP-144 was reversed by treatment with progesterone.


Accession: 005151486

PMID: 6818022

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Yamazaki, I., 1982: Differences in the pregnancy-terminating effectiveness of an LH-RH analogue by subcutaneous, vaginal, rectal, and nasal routes in rats. A long-acting analogue of LH-RH, des-Gly10-[D-Leu6]-LH-RH-ethylamide (TAP-144), was administered once or twice on day 9 of pregnancy by subcutaneous, vaginal, rectal, and nasal routes to rats; the pregnancy-terminating effectiveness of these route...

Okada, H.; Yamazaki, I.; Ogawa, Y.; Hirai, S.; Yashiki, T.; Mima, H., 1982: Vaginal absorption of a potent lhrh analog leuprolide in rats 1. absorption by various routes and absorption enhancement. The absorption of a potent LHRH analog (leuprolide) through different routes was evaluated by determining the ovulation-inducing activity in diestrous rats. Vaginal administration showed the greatest potency among nonparenteral routes and was foll...

Yamazaki, I., 1984: Serum concentration patterns of an LHRH agonist, gonadotrophins and sex steroids after subcutaneous, vaginal, rectal and nasal administration of the agonist to pregnant rats. A highly potent LHRH agonist, des-Gly10-[D-Leu6]-LHRH-ethylamide (TAP-144), was administered by subcutaneous, vaginal, rectal and nasal routes to pregnant rats on Day 10. After subcutaneous administration, almost all the TAP-144 was rapidly absorb...

Yamazaki I., 1984: Serum concentration patterns of an lhrh agonist gonadotropins and sex steroids after subcutaneous vaginal rectal and nasal administration of the agonist to pregnant rats. A highly potent LHRH agonist, des-Gly10-[D-Leu6]-LHRH-ethylamide (TAP-144), was administered by s.c., vaginal, rectal and nasal routes to pregnant rats on day 10. After s.c. administration, almost all the TAP-144 was rapidly absorbed and eliminate...

Luder A.S.; Holland F.J.; Costigan D.C.; Jenner M.R.; Wielgosz G.; Fazekas A.T.A., 1984: Intra nasal and sub cutaneous treatment of central precocious puberty in both sexes with a long acting analog of lhrh. The chronic administration of the long-acting LHRH agonist analog D-Ser(TBU)6-LHRH-EA10 (HOE 766, Buserelin) suppresses pituitary gonadotropin secretion. Since a similar analog was effective in the short term parenteral treatment of idiopathic pre...

Okada, H.; Yashiki, T.; Mima, H., 1983: Vaginal absorption of a potent lhrh analog leuprolide in rats 3. effect of estrous cycle on vaginal absorption of hydrophilic model compounds. The effect of estrous cycle stages on vaginal absorption was determined by the use of insulin, phenolsulfonphthalein and salicylic acid as hydrophilic model compounds. Absorption of these compounds was markedly affected by the stage, possibly due...

Das C.; Talwar G.P., 1983: Pregnancy terminating action of lhrh hormone agonist 6 tert butyl d serine des 10 glycinamide lhrh ethylamide in baboons. Injections (s.c.) of LHRH agonist D-Ser(But)6desGly10ProEA given to 6 pregnant baboons at 8-h or 12-h intervals over a period of 4-6 days around the time of the appearance of chorionic gonadotropin in the circulation diminished the plasma progeste...

Han, K.; Park, J.S.; Jeong, Y.B.; Robinson, J.R., 1994: Enzymatic proteolysis of LHRH and inhibitory effect of medium chain fatty acids salts in rabbit rectal, nasal and vaginal mucosa. Pharmaceutical Research (New York) 11(10 SUPPL ): S280

Kumasaka T.; Yaoi Y.; Nishi N.; Saito M.; Arimura A.; Coy D.H.; Schally A.V., 1976: Clinical studies on a potent analog of luteinizing hormone releasing hormone by vaginal and rectal routes. Acta Obstetrica et Gynaecologica Japonica (English Edition) 23(4): 323

Yamazaki, I., 1982: Pregnancy terminating effect of a highly active LH-RH agonist by vaginal application in rats. A potent LH-RH agonist, des-Gly10-[D-Leu6]-LH-RH-ethylamide (TAP-144), administered to pregnant rats by the intravaginal and subcutaneous routes terminated pregnancy most effectively during days 7-11 of pregnancy. A daily administration of TAP-144...