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Differences in the regulation of humoral responses between mice infected with trypanosoma cruzi and mice administered trypanosoma cruzi induced suppressor substance

Differences in the regulation of humoral responses between mice infected with trypanosoma cruzi and mice administered trypanosoma cruzi induced suppressor substance

Journal of Immunology 125(5): 2317-2321

The effects of T. cruzi and the T. cruzi-induced serum suppressor substance (SSS) on antibody responses were compared. Although infection with T. cruzi led to an alteration in T cell helper activity and a reduced specific B cell precursor frequency, SSS did not have a similar effect on either of these cell populations. The characteristics of the altered T cell helper activity was further investigated. Helper activity appeared earlier in infected mice than in normal or SSS- suppressed mice, and less antigen was required for optimal elicitation of T helper cells in infected mice. The potency of T cell helper activity differed in the order T. cruzi-infected > normal > SSS-suppressed mice. Spleen cells from T. cruzi-infected mice elaborated more potent specific helper factors than spleen cells from normal or SSS-suppressed mice, but did not produce a detectable nonspecific helper factor in vitro. The addition of B cells from low-dose primed, T. cruzi-infected mice to cultures of normal spleen cells resulted in subnormal responses to the priming antigen (sheep erythrocytes) but not to another unrelated antigen (trinitrophenyl-haptenated Brucella abortus); similarly sensitized B cells from normal or SSS-suppressed mice caused no such effect.

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Accession: 005151540

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