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Differences in the regulation of humoral responses between mice infected with trypanosoma cruzi and mice administered trypanosoma cruzi induced suppressor substance

, : Differences in the regulation of humoral responses between mice infected with trypanosoma cruzi and mice administered trypanosoma cruzi induced suppressor substance. Journal of Immunology 125(5): 2317-2321

The effects of T. cruzi and the T. cruzi-induced serum suppressor substance (SSS) on antibody responses were compared. Although infection with T. cruzi led to an alteration in T cell helper activity and a reduced specific B cell precursor frequency, SSS did not have a similar effect on either of these cell populations. The characteristics of the altered T cell helper activity was further investigated. Helper activity appeared earlier in infected mice than in normal or SSS- suppressed mice, and less antigen was required for optimal elicitation of T helper cells in infected mice. The potency of T cell helper activity differed in the order T. cruzi-infected > normal > SSS-suppressed mice. Spleen cells from T. cruzi-infected mice elaborated more potent specific helper factors than spleen cells from normal or SSS-suppressed mice, but did not produce a detectable nonspecific helper factor in vitro. The addition of B cells from low-dose primed, T. cruzi-infected mice to cultures of normal spleen cells resulted in subnormal responses to the priming antigen (sheep erythrocytes) but not to another unrelated antigen (trinitrophenyl-haptenated Brucella abortus); similarly sensitized B cells from normal or SSS-suppressed mice caused no such effect.

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