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Differences in the regulation of megakaryocytopoiesis in the murine bone marrow and spleen

, : Differences in the regulation of megakaryocytopoiesis in the murine bone marrow and spleen. Leukemia Research 6(5): 721-728

Murine splenic megakaryocytopoiesis was analyzed and compared to that of the bone marrow. Quantification of megkaryocytes by acetylcholinesterase staining indicated a reduction in the total numbers of megakaryocytes in the spleen, with the largest decrease being in the total numbers of immature megakaryocytes. On a per organ basis, the spleen also contained a lower number of the megakaryocyte progenitor cells (CFU-Mk) than the bone marrow. The splenic and bone marrow progenitor cells had similar in vitro responses to megakaryocyte colony-stimulating activities. The splenic progenitor cells developed a lower number of megakaryocytes per colony, compared to bone marrow. This lower number of cell divisions was not compensated by increased endomitotic activity, since the splenic colony megakaryocytes had a similar distribution of DNA to those derived from marrow megakaryocytes. Cell cycle analysis indicated that, in contrast to marrow cells, splenic megakaryocyte progenitor cells are a rapidly-cycling population. This change in cell cycle status, together with altered proportions of progenitor cells, immature and mature megakaryocytes, suggests that the regulation and kinetics of megakaryocyte development are different in spleen and bone marrow.

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Accession: 005151541

PMID: 7154708

DOI: 10.1016/0145-2126(82)90089-3

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Selkirk, J.V.; Challiss, R.A.John.; Rhodes, A.; McIlhinney, R.A.Jeffrey., 2002: Characterization of an N-terminal secreted domain of the type-1 human metabotropic glutamate receptor produced by a mammalian cell line. A Chinese hamster ovary cell line has been established which secretes the N-terminal domain of human mGlu1 receptor. The secreted protein has been modified to contain a C-terminal hexa-histidine tag and can be purified by metal-chelate chromatogra...

Greyson, R.I.; Walden, D.B., 1976: Abphyl - genetically based variability leaf arrangement in Zea mays. Leaf arrangement in these plants varies from spiral to decussate. The character is transmitted through either the male or female parent and has been maintained for ten generations. Several dozen varieties have been established, some yielding proge...

Mesguich, C.; Cazeau, A-Laure.; Bouabdallah, K.; Soubeyran, P.; Guyot, M.; Milpied, Nël.; Bordenave, L.; Hindié, E., 2016: Hodgkin lymphoma: a negative interim-PET cannot circumvent the need for end-of-treatment-PET evaluation. NlmCategory="UNASSIGNED">We examined the outcome of a cohort of patients with Hodgkin lymphoma (HL) in order to assess if fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) at the end of treatment (end-...

Westaway Rob, 1989: Northeast Basin and Range Province active tectonics; an alternative view. Geology (Boulder) 17(9): 779-783

Rankin-Box, D.F., 1996: Is there a place for complementary therapies in the accident and emergency department?. This paper addresses the potential for complementary therapies in the Accident and Emergency (A & E) department. It is suggested that whilst there are a number of therapies which may be efficacious in emergency settings, nurses need to con...

Rofman, O.V.; Bate, P.S.; Brough, I.; Humphreys, F.J., 2009: Study of dynamic grain growth by electron microscopy and EBSD. The effect of hot deformation on fully recrystallized aluminium-copper alloys (Al-4wt%Cu and Al-33wt%Cu) with different volume fractions of CuAl(2) has been studied. The alloys are Zener pinned systems with different superplastic properties. Strai...

Cui Yue., 1999: Analyzing the influence of grazing on the grasshopper community in steppe using GIS. Acta Veterinaria et Zootechnica Sinica. Nov; 306: 574-576

Matzhold, E.M.; Trummer, O.; Grünbacher, G.; Zulus, B.; Boehm, B.O.; März, W.; Renner, W., 2009: Association of polymorphisms in the chemokine receptor CX3CR1 gene with coronary artery disease. Two chemokine receptor CX3CR1 gene variants, V249I and T280M, have been implicated in coronary artery diseases (CAD). Currently no consistent effect has been revealed and their role in cardiovascular disease is still conflicting. In the present st...

Chen P.; Zhang Z Q.; X.W.; Wang K.; Zhu G.; L.L.; Liu H., 1991: Effects of chemical control of the cotton aphid during the early season on cotton plants on natural enemies and yield. Studies on effects of chemical control of the cotton aphid during the early season on (1) the growth and fruiting characteristic and yield of cotton, and (2) pest and natural enemy number and pest damage during the mid and late season, were conduc...

Rogister, B.; Delrée, P.; Leprince, P.; Martin, D.; Sadzot, C.; Malgrange, B.; Munaut, C.; Rigo, J.M.; Lefebvre, P.P.; Octave, J.N., 1993: Transforming growth factor beta as a neuronoglial signal during peripheral nervous system response to injury. In contrast to the central nervous system (CNS), the peripheral nervous system (PNS) displays an important regenerative ability which is dependent, at least in part, on Schwann cell properties. The mechanisms which stimulate Schwann cells to adapt...