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Differences in the release of melanocyte stimulating hormone in vitro by rat pituitary glands collected at various times during the estrous cycle


Journal of Endocrinology 78(1): 1-6
Differences in the release of melanocyte stimulating hormone in vitro by rat pituitary glands collected at various times during the estrous cycle
The release of melanocyte-stimulating hormone (MSH) into the medium during incubation and the pituitary tissue content of MSH were measured separately using pituitary glands collected from rats at various stages of the estrous cycle. The MSH was measured by a biological assay using a synthetic .alpha.-MSH as standard. The release of MSH was maximal during the proestrous phase, and MSH content of the pituitary gland was highest during diestrus. The influences of the tripeptide Pro-Leu-Gly-NH2, which inhibits MSH secretion in vivo, and of progesterone on the release of MSH in vitro were studied with tissue collected at various phases of the estrous cycle. Pro-Leu-Gly-NH2 was effective in inhibiting MSH release both at proestrus and estrus but not at diestrus. Progesterone overcame this inhibition.


Accession: 005151548

PMID: 567239



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