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Differences in the responses of brain cytosolic and mitochondrial hexokinases ec 2.7.1.1 to 3 essential divalent metal ions


, : Differences in the responses of brain cytosolic and mitochondrial hexokinases ec 2.7.1.1 to 3 essential divalent metal ions. Comparative Biochemistry and Physiology C Pharmacology Toxicology and Endocrinology 80(2): 285-290

Rat brain cytosolic and mitochondrial hexokinase activities were undetectable without added divalent cations. Mg2+ activated cytosolic (K0.5 [median activity] of Mg2+ = 343 .+-. 13 .mu.M) and mitochondrial (K0.5 of Mg2+ = 183 .+-. 8 .mu.M) hexokinase in a concentration-related manner. The corresponding values for Mn2+ were 702 .+-. 99 and 413 .+-. 21 .mu.M, respectively. Ca2+, however, activated both forms of hexokinase poorly. In the presence of Mg2+, both Mn2+ and Cu2+ were more potent inhibitors of cytosolic hexokinase than mitochondrial hexokinase, whereas the inhibition of Cd2+ and Ca2+ did not show such selectivity. Evidently, brain mitochondrial and cytosolic hexokinases differ significantly in their responses to divalent cations.

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