+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Differences in the responses of brain cytosolic and mitochondrial hexokinases ec to 3 essential divalent metal ions

, : Differences in the responses of brain cytosolic and mitochondrial hexokinases ec to 3 essential divalent metal ions. Comparative Biochemistry and Physiology C Pharmacology Toxicology and Endocrinology 80(2): 285-290

Rat brain cytosolic and mitochondrial hexokinase activities were undetectable without added divalent cations. Mg2+ activated cytosolic (K0.5 [median activity] of Mg2+ = 343 .+-. 13 .mu.M) and mitochondrial (K0.5 of Mg2+ = 183 .+-. 8 .mu.M) hexokinase in a concentration-related manner. The corresponding values for Mn2+ were 702 .+-. 99 and 413 .+-. 21 .mu.M, respectively. Ca2+, however, activated both forms of hexokinase poorly. In the presence of Mg2+, both Mn2+ and Cu2+ were more potent inhibitors of cytosolic hexokinase than mitochondrial hexokinase, whereas the inhibition of Cd2+ and Ca2+ did not show such selectivity. Evidently, brain mitochondrial and cytosolic hexokinases differ significantly in their responses to divalent cations.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 005151568

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Theissen, J.L.; Fischer, S.R.; Traber, L.D.; Traber, D.L., 1995: Pulmonary blood flow regulation: influence of positive pressure ventilation. Positive pressure ventilation with PEEP has been reported to reduce hypoxic pulmonary vasoconstriction (HPV) and thus increase venous admixture. This effect was investigated in six chronically instrumented unanesthetized healthy sheep. The change...

Anonymous, 2002: In memory of Georgiy Nikolayevich Shaposhnikov. Otechestvennaya Geologiya 2002(1): 84-85

Buser, H. R., 1976: Preparation of qualitative standard mixtures of poly chlorinated di benzo p dioxins and di benzo furans by uv and gamma irradiation of the octa chloro compounds. High-resolution gas chromatography using an OV-17 glass capillary column and mass spectrometry were used to analyze UV- and .gamma.-irradiated octachlorodibenzo-p-dioxin and octachlorodibenzofuran. Under the conditions investigated, dechlorination...

Schlichenmeyer, K.J.; Dube, W.V.; Vargas-Irwin, M., 2015: Stimulus Fading and Response Elaboration in Differential Reinforcement for Alternative Behavior. Behavioral Interventions 30(1): 51-64

Rogers, D.J.; Cole, L.M.; Fraser, T.M.; Walker, J.T.S., 2007: Potential strategies to manage bronze beetle (Eucolaspsis sp.) in organic apple orchards. Bronze beetle (Eucolaspsis sp., Coleoptera: Chrysomelidae) threatens the viability of New Zealand's organic pipfruit industry. Small plot cultivation trials were conducted during spring to target immature beetles in the soil in a 2.5 m strip...

Avice, G.; Marty, B., 2014: The iodine-plutonium-xenon age of the Moon-Earth system revisited. Iodine-plutonium-xenon isotope systematics have been used to re-evaluate time constraints on the early evolution of the Earth-atmosphere system and, by inference, on the Moon-forming event. Two extinct radionuclides ((129)I, T1/2=15.6 Ma and (24...

Ilinskii, Yu-Yu; Zakharov, I.K., 2007: Infection of drosophila melanogaster population in Uman by cytoplasmic endosymbiotic Wolbachia. Doklady Akademii Nauk 413(4): 561-563

Dean, R.S.; Gray, J.W.; Anderson, J.L., 1996: Underlying factor structure of perinatal events. The underlying factor structure of perinatal events was examined for 847 children (272 normals, 117 developmentally disabled, 37 speech disordered, 221 learning disordered, 91 emotionally disturbed, and 109 Head Start children). Pertinent perinata...

Castiblanco, C.; Foster, C.Stephen., 2014: Review of Systemic Immunosuppression for Autoimmune Uveitis. The purpose of this review is to comprehensively examine the various therapeutic agents available to treat autoimmune eye disease, their indications, clinical safety and recent developments. The stepladder approach is reviewed, including corticost...

Albanese, A.; Lalli, S., 2012: Update on dystonia. This review considers the recent literature pertaining to the clinical features, genetics, neuropathology and treatment of dystonia syndromes. The term dystonia indicates at the same time a clinical phenotype and a collection of neurological syndr...