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Differences in the stereotypy response but not the hypo motility response to apo morphine in the roman high avoiding and roman low avoiding strains of rats

, : Differences in the stereotypy response but not the hypo motility response to apo morphine in the roman high avoiding and roman low avoiding strains of rats. Psychopharmacology 82(3): 215-220

Two experiments were carried out to study differences in the behavioral responses to high and low doses of apomorphine [APO] in 2 strains of rats selectively bred for high and low avoidance on a 2-way active avoidance task: the Roman High and Low Avoiders. Significant strain differences were found in the sereotypy resulting from a high dose of APO (2 mg/kg s.c.). In experiment 2, no strain differences were found for the hypomotility produced by low doses of the drug (0.05 mg/kg s.c.). Pretreatment with a low dose of APO had no effect on the stereotypy response when the animals were subsequently retested with the high dose. These results may indicate differential sensitivities of dopamine receptors in these strains.

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