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Differences in the uptake of transferrin bound plutonium 239 and iron 59 into multicellular spheroids of hepatocytes from adult male rats


, : Differences in the uptake of transferrin bound plutonium 239 and iron 59 into multicellular spheroids of hepatocytes from adult male rats. International Journal of Radiation Biology & Related Studies in Physics Chemistry & Medicine 52(6): 883-892

Hepatocytes were cultured as monolayers and multicellular spheroids, respectively. The uptake of both transferrin-bound metals, iron and plutonium, differed significantly between these two culture systems. The uptake into the multicellular spheroids for plutonium was about 30 times greater, and for iron about 4 times greater, than in monolayer-cultured hepatocytes, which is not a consequence of proliferation and/or de-differentiation of the hepatocytes in the multicellular spheroid culture system. A comparison of the iron and platonium uptake showed that plutonium was delivered to the cells to an 8-fold greater extent than iron if the hepatocytes were cultured as spheroids. Additionally, the binding of plutonium was not inhibited by preincubation of the spheroids with the iron-transferrin complex. Therefore, we propose that there are two different binding sites for iron and plutonium on hepatocytes membranes.

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