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Differences in thymus dependency among the allo reactive t cell sub populations in their development graft vs. host reaction appears to be mediated by delayed type hyper sensitivity of tuberculin type


, : Differences in thymus dependency among the allo reactive t cell sub populations in their development graft vs. host reaction appears to be mediated by delayed type hyper sensitivity of tuberculin type. Cellular Immunology 81(2): 403-412

The effects of thymectomy at various times after birth, 1 and 7 days (Tx-1, Tx-7), on delayed footpad reactions, cell-mediated cytotoxicity (CMC), production of migration inhibitory factor (MIF) and graft-vs.-host reactions (GVHR) against allogeneic antigens were determined by experiments with 8-wk-old mice. Delayed footpad reactions were detected in Tx-1 mice, but CMC, production of MIF, and the ability to raise GVHR were not detected in such mice. CMC was detected in Tx-7 mice. The ability to raise GVHR and to produce MIF was abolished by thymectomy at 7 days after birth. The effector mechanism to mount a GVHR might be mediated by delayed-type hypersensitivity of tuberculin type rather than CMC to host antigens.

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