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Differences in thymus dependency among the allo reactive t cell sub populations in their development graft vs. host reaction appears to be mediated by delayed type hyper sensitivity of tuberculin type


, : Differences in thymus dependency among the allo reactive t cell sub populations in their development graft vs. host reaction appears to be mediated by delayed type hyper sensitivity of tuberculin type. Cellular Immunology 81(2): 403-412

The effects of thymectomy at various times after birth, 1 and 7 days (Tx-1, Tx-7), on delayed footpad reactions, cell-mediated cytotoxicity (CMC), production of migration inhibitory factor (MIF) and graft-vs.-host reactions (GVHR) against allogeneic antigens were determined by experiments with 8-wk-old mice. Delayed footpad reactions were detected in Tx-1 mice, but CMC, production of MIF, and the ability to raise GVHR were not detected in such mice. CMC was detected in Tx-7 mice. The ability to raise GVHR and to produce MIF was abolished by thymectomy at 7 days after birth. The effector mechanism to mount a GVHR might be mediated by delayed-type hypersensitivity of tuberculin type rather than CMC to host antigens.

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Related references

Kawauchi, H.; Taniguchi, K.; Kato, M.; Shimamoto, Y.; Kubo, C.; Nomoto, K., 1983: Differences in thymus dependency among the alloreactive T-cell subpopulations in their development: graft-versus-host reaction appears to be mediated by delayed-type hypersensitivity of tuberculin type. The effects of thymectomy at various times after birth, 1 and 7 days (Tx-1, Tx-7), on delayed footpad reactions, cell-mediated cytotoxicity (CMC), production of migration inhibitory factor (MIF), and graft-versus-host reactions (GVHR) against allo...

Ohmichi, Y.; Nomoto, K.; Yamada, H.; Takeya, K., 1976: Relationships among differentiated thymus derived cell sub populations part 1 dissociated development of tuberculin type hyper sensitivity jones mote type hyper sensitivity and activation of helper function. Relationships among tuberculin type hypersensitivity, Jones-Mote type hypersensitivity and activation of helper T [thymus-derived] cells were studied in AKR mice by footpad reaction, migration inhibition test and antibody production against the tr...

Kawauchi H., 1983: Studies of differences in thymus dependency among the allo reactive t cell sub populations in their development. The difference in thymus-dependency among alloreactive T cell subpopulations in their development was determined by the estimation of effects of thymectomy at various times after birth on different immune responses observed at 8 wk of age. The per...

Strassmann, G.; Eshhar, Z.; Mozes, E., 1980: Genetic regulation of delayed type hyper sensitivity responses to a branched peptide containing tyrosine glutamic acid alanine and lysine 2. evidence for a thymus derived cell thymus derived cell collaboration in delayed type hyper sensitivity responses and for a thymus derived cell defect at the efferent phase in nonresponder h 2k mice. The intercellular interactions and the site of the genetic defect in delayed-type hypersensitivity (DTH) response to poly(L-Tyr,L-Glu)-poly(DL-Ala).sbd.poly(L-Lys) [(T,G)-A.sbd.L] was studied in a system where the T [thymus-derived] cell education...

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Whisler R.L.; Stobo J.D., 1977: Thymus derived cell sub populations suppressing humoral and delayed type hyper sensitivity responses. Journal of Supramolecular Structure SUPPL: 1

Huber, B.; Devinsky, O.; Gershon, R.K.; Cantor, H., 1976: Cell mediated immunity delayed type hyper sensitivity and cyto toxic responses are mediated by different thymus derived cell subclasses. Cell-mediated immunity includes the generation of cytotoxic cells and initiation of delayed-type hypersensitivity (DTH). The resting T[thymus-derived]-cell population, before stimulation by antigen, already contains cells of the Ly1 subclass that...

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