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Differences in tumor and normal tissue concentrations of iodine and indium labeled monoclonal antibody i. the effect on image contrast in clinical studies


, : Differences in tumor and normal tissue concentrations of iodine and indium labeled monoclonal antibody i. the effect on image contrast in clinical studies. European Journal of Nuclear Medicine 11(8): 295-299

The poor imaging characteristics of 131I have resulted in the use of alternative radionuclides for radiolabelling monoclonal antibodies. Clinical imaging studies have shown that, in addition to the more suitable energy of emission of 111In over 131I for gamma camera detection, the 111In-labelled antibody appears to celar from the blood-stream at a faster rate than that of 131-labelled antibody, resulting in greater tumour-to-background image contrast. However, measurements of the activity in blood samples from patients demonstrate that both 131I- and 111In-labelled antibodies clear from the circulation at similar rate. This discrepancy is probably due to the different biological fates of the two radionuclides and warrants further scientific study.

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Accession: 005151703

PMID: 4076237

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Perkins, A.C.; Pimm, M.V., 1985: Differences in tumour and normal tissue concentrations of iodine- and indium-labelled monoclonal antibody. I. The effect on image contrast in clinical studies. The poor imaging characteristics of 131I have resulted in the use of alternative radionuclides for radiolabelling monoclonal antibodies. Clinical imaging studies have shown that, in addition to the more suitable energy of emission of 111In over 13...

Pimm, M.V.; Perkins, A.C.; Baldwin, R.W., 1985: Differences in tumor and normal tissue concentrations of iodine and indium labeled monoclonal antibody ii. biodistribution studies in mice with human tumor xenografts. The blood, tumour and whole-body levels and survivals of 131I- and 111In-labelled monoclonal antibody (791T/36) have been compared in mice with human tumour xenografts. The blood levels and survivals of 131I- and 111In-labelled antibody were simil...

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