EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Differences in virulence for mice between disease and carrier strains of Neisseria meningitidis


Canadian Journal of Microbiology 27(7): 738-741
Differences in virulence for mice between disease and carrier strains of Neisseria meningitidis
The virulence of 11 prototype strains of Neisseria meningitidis, which had been used in the development of the serotyping scheme for serogroup B meningococci, were examined in mice treated with iron dextran. These strains, together with those previously examined, allowed for a good assessment of the virulence differences between carrier and disease strains. All of a total of 17 disease strains displayed virulence for mice (60% with high virulence), whereas only approximately 50% of 13 carrier strains possessed virulence (only 15% with high virulence). Because the ability to initiate infection in mice is independent of exogenous iron, this model system for infection appears particularly suited to studies of the physiological bases for virulence in N. meningitidis.


Accession: 005151736

PMID: 6794895

DOI: 10.1139/m81-113



Related references

Virulence markers in patient and carrier strains of Neisseria meningitidis. Scandinavian Journal of Infectious Diseases 16(3): 267-270, 1984

Neisseria meningitidis infection in mice: influence of iron, variations in virulence among strains, and pathology. Infection and Immunity 24(2): 545-551, 1979

Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis. Proceedings of the National Academy of Sciences of the United States of America 105(9): 3473-3478, 2008

Proinflammatory responses to lipo-oligosaccharide of Neisseria meningitidis immunotype strains in relation to virulence and disease. Journal of Infectious Diseases 185(10): 1431-1438, 2002

Distribution of serogroups and sequence types in disease-associated and carrier strains of Neisseria meningitidis isolated in China between 2003 and 2008. Epidemiology and Infection 140(7): 1296-1303, 2012

Use of arbitrarily primed polymerase chain reaction analysis to type disease and carrier strains of Neisseria meningitidis isolated during a university outbreak. Journal of Infectious Diseases 169(6): 1384-1389, 1994

Superoxide dismutase catalase and peroxidase in 4 strains of neisseria meningitidis of different virulence. FEMS Microbiology Letters 25(1): 71-74, 1984

Use of the chick embryo for the determination of the relative virulence of Neisseria meningitidis strains. Annals of the New York Academy of Sciences 730: 266-268, 1994

Serum resistance discriminates group b but not c or y neisseria meningitidis case and carrier strains. Clinical Research 33(2 PART 1): 418A, 1985

Carrier rate of Neisseria meningitidis and the occurrence of sulfonamide resistant strains in Lebanon. Le Journal Medical Libanais. Lebanese Medical Journal 26(5): 495-500, 1973