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Different autochthonous models of colorectal cancer in the rat

Journal of Cancer Research & Clinical Oncology 111(2): 157-159
Different autochthonous models of colorectal cancer in the rat
Chemically induced (autochthonous) tumors in the rodent are thought to be the best models at hand to obtain results transferable to the clinical situation. Four different autochthonous tumor models: 1,2-dimethylhydrazine, N-methylnitrosourea (MNU), N-methyl-N-nitro-nitrosoguanidine (MNNG), and N-nitroso-acetoxymethyl-methylamine (AMMN) which are used worldwide for etiological and therapy studies of colon cancer are compared for tumor biology and clinical relevance. The four tumor models of colon carcinoma described in the rat are different in growth, invasion, and metastases. The choice of the selected tumor model for experimental investigations of colon cancer should depend on the clinical question.

Accession: 005151894

PMID: 3700460

DOI: 10.1007/bf00400756

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