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Different behavioral mechanisms underlie tolerance to the anorectic effects of fenfluramine and quipazine


, : Different behavioral mechanisms underlie tolerance to the anorectic effects of fenfluramine and quipazine. Psychopharmacology 81(2): 155-157

Chronic administration of fenfluramine or quipazine in rats before scheduled daily feeding sessions led to rapid and complete tolerance to the initial anorexia. Daily injections of fenfluramine after the daily meal also led to full tolerance. Quipazine administration after meals led to the development of little tolerance, indicating that quipazine tolerance appears to be learned or contingent. The implications of these data for neurochemical mechanisms of satiety are discussed.

Accession: 005151920

PMID: 6415747

DOI: 10.1007/bf00429011

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Related references

Willner P.; Mcguirk J.; Phillips G.; Muscat R., 1990: Behavioral analysis of the anorectic effects of fluoxetine and fenfluramine. Two sets of experiments were carried out to compare the effects of fenfluramine and fluoxetine on consummatory and operant behaviour. In food-deprived rats allowed access to a 35% sucrose solution, an initial period of sucrose consumption was foll...

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Caccia, S.; Anelli, M.; Fracasso, C.; Frittoli, E.; Giorcelli, P.; Gobbi, M.; Taddei, C.; Garattini, S.; Mennini, T., 1993: Anorectic effect of brain concentrations of D-fenfluramine in the marmoset: Relationship to the in vivo and in vitro effects on serotonergic mechanisms. The present study investigated the anorectic activity of d-fenfluramine (d-F) and the relationship with brain levels of unchanged drug and its metabolite d-norfenfluramine (d-NF) in marmosets, relating them to neurochemical effects on the serotoni...

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