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Different behavioral patterns induced by apo morphine evidence that the method of administration determines the behavioral response to the drug


European Journal of Pharmacology 46(1): 41-50
Different behavioral patterns induced by apo morphine evidence that the method of administration determines the behavioral response to the drug
The behavioral effects of s.c. injected apomorphine were studied on habituated rats in a test-box designed to measure 8 different components of behavior. Apomorphine, 1 mg/kg, induced 2 different behaviors: the G-type of behavior characterized by compulsive gnawing and the LS-type characterized by increased locomotion, sniffing and repetitive head and limb movements. G-type behavior was induced when apomorphine, dissolved by heating, was injected s.c. into the flank of the animal. LS-type behavior was induced when apomorphine, dissolved by heating, was injected s.c. into the neck and when it was dissolved by heating together with a high concentration of ascorbic acid (1 mg/ml) and injected s.c. into the flak. G-type behavior could not be elicited by changing the dose which induced LS-type behavior of vice versa. Apparently these different behavioral effects of apomorphine were not dose-response effects, but were elicited by at least 2 different synaptic mechanisms in the brain. Experimentally induced changes from 1 of these apomorphine-induced behaviors to another can therefore not merely be interpreted as a change in the intensity of the behavioral response as is done in, e.g., commonly used stereotypy rating scales.


Accession: 005151921

PMID: 562766



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