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Different behavioral patterns induced by apo morphine evidence that the method of administration determines the behavioral response to the drug


, : Different behavioral patterns induced by apo morphine evidence that the method of administration determines the behavioral response to the drug. European Journal of Pharmacology 46(1): 41-50

The behavioral effects of s.c. injected apomorphine were studied on habituated rats in a test-box designed to measure 8 different components of behavior. Apomorphine, 1 mg/kg, induced 2 different behaviors: the G-type of behavior characterized by compulsive gnawing and the LS-type characterized by increased locomotion, sniffing and repetitive head and limb movements. G-type behavior was induced when apomorphine, dissolved by heating, was injected s.c. into the flank of the animal. LS-type behavior was induced when apomorphine, dissolved by heating, was injected s.c. into the neck and when it was dissolved by heating together with a high concentration of ascorbic acid (1 mg/ml) and injected s.c. into the flak. G-type behavior could not be elicited by changing the dose which induced LS-type behavior of vice versa. Apparently these different behavioral effects of apomorphine were not dose-response effects, but were elicited by at least 2 different synaptic mechanisms in the brain. Experimentally induced changes from 1 of these apomorphine-induced behaviors to another can therefore not merely be interpreted as a change in the intensity of the behavioral response as is done in, e.g., commonly used stereotypy rating scales.

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Barefoot S.M., 1983: Air flow characteristics of fricative consonants produced by normally hearing and hearing impaired speakers. The rates of airflow for fricative consonants produced by normally hearing speakers and by hearing-impaired speakers, who varied in degree of hearing loss and speech intelligibility, were compared. Subjects consisted of 20 normally hearing adults...

Fields, E. S., 1966: Tests with a Dichlorvos aerosol for control of cockroaches on busses. Tests with an aerosol composed of 5% dichlorvos (Technical), 10% methyl chloroform and 85% propellent were successful in ridding busses of cockroach infestations with exposures of from 45 minutes to 1 hr. at temperatures between 70? to 85?F. Two 1...

Lamar John Everts, 1930: Relation of texture to the development of porosity by weathering. Geological Society of America Bulletin 41(1): 167

Matsumura K.; Nakagawa T.; Taguchi M.; Shinoda N., 1982: Free thyroxine measurement with amerlex free thyroxine kit. Kaku Igaku 19(4): 637

Basu, S. K.; Mukherjee, D. P., 1972: Studies on the germination of palm seeds. Fresh ripe seeds of about 30 species, including Areca catechu, Elaeis guineensis, Phoenix canariensis and several ornamental palms, were sown in sand after cleaning and the number of days to germinate was recorded for each. Apart from 4 spp. (incl...

Anonymous, 1978: Metering pumps in dairy processing. A brief account with diagrammatic illustrations is given of metering pumps for use in the manufacture of various dairy products, including butter (water, salt and starter addition), quarg (addition of cream, fruit juices, purees and stabilizers),...

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Marin, P. D.; Boza, P.; Merkulov, L. J.; Krstic, B.; Petkovic, B.; Veljic, M.; Pajevic, S., 1998: Seed sculpturing of selected European Vicia L. species (Fabaceae) and their taxonomical evaluation. Seed sculpturing of 26 Vicia taxa, belonging to the sections Ervum, Cracca, Faba and Vicia, was analysed using a scanning electron microscope (SEM). The anticlinal seed testa transections of Vicia sativa, V. lathyroides and V. hirsuta were also st...

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