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Different behavioral patterns induced by apo morphine evidence that the method of administration determines the behavioral response to the drug

, : Different behavioral patterns induced by apo morphine evidence that the method of administration determines the behavioral response to the drug. European Journal of Pharmacology 46(1): 41-50

The behavioral effects of s.c. injected apomorphine were studied on habituated rats in a test-box designed to measure 8 different components of behavior. Apomorphine, 1 mg/kg, induced 2 different behaviors: the G-type of behavior characterized by compulsive gnawing and the LS-type characterized by increased locomotion, sniffing and repetitive head and limb movements. G-type behavior was induced when apomorphine, dissolved by heating, was injected s.c. into the flank of the animal. LS-type behavior was induced when apomorphine, dissolved by heating, was injected s.c. into the neck and when it was dissolved by heating together with a high concentration of ascorbic acid (1 mg/ml) and injected s.c. into the flak. G-type behavior could not be elicited by changing the dose which induced LS-type behavior of vice versa. Apparently these different behavioral effects of apomorphine were not dose-response effects, but were elicited by at least 2 different synaptic mechanisms in the brain. Experimentally induced changes from 1 of these apomorphine-induced behaviors to another can therefore not merely be interpreted as a change in the intensity of the behavioral response as is done in, e.g., commonly used stereotypy rating scales.

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