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Different blood pressure response to deoxy cortico sterone acetate sodium chloride treatment in auto immune and n n' di acetyl benzidine induced nephropathies


, : Different blood pressure response to deoxy cortico sterone acetate sodium chloride treatment in auto immune and n n' di acetyl benzidine induced nephropathies. Acta Pathologica et Microbiologica Scandinavica Section C Immunology 89(3): 193-198

To explore the effect of immunologically-induced nephropathy vs. a nonimmunological model on development of hypertension, rats with Heymann nephritis or N,N-diacetylbenzidine (N,N'-DAB)-induced nephropathy were subjected to DOCA-NaCl [deoxycorticosterone acetate sodium chloride] treatment. Hypertension developed during DOCA-NaCl treatment in Heymann nephritic rats but not in rats with N,N'-DNAB nephropathy, despite similar degrees of proteinuria and other features of nephrosis. There were no signs of different fluid balance, either. Azotemia did not ensue. Histology and immunohistology showed membranous glomerulonephritis in Heymann nephritic rats; glomerular epithelial cell alterations without immune deposits along the glomerular capillary walls were seen in rats with N,N'-DAB nephropathy. The type of renal damage or factors mediating such damage appear to be important determinants for the hypertensive response of Heymann nephritic rats to DOCA-NaCl treatment.

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