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Different bronchoconstrictor effects of carbachol boluses inhaled near residual volume or total lung capacity

, : Different bronchoconstrictor effects of carbachol boluses inhaled near residual volume or total lung capacity. Respiration; International Review of Thoracic Diseases 51(2): 81-85

The purpose of this study was to determine if the lung volume at which aerosol inhalation begins (LVi) influences airway responses to bronchoconstrictor agents. We compared the effects of carbachol boluses (25, 50 and 100 ml), inhaled at high and low LVi (averaging 72.2 and 15.8% of vital capacity, respectively) on specific airway resistance (SRaw). In order to eliminate the possible influence of airway obstruction on aerosol distribution and deposition, we selected 5 asthmatic subjects with normal respiratory function (spirometry, SRaw, nitrogen washout and closing volume); furthermore, non-cumulative dose-response curves were obtained (i.e. the patients inhaled only one dose of carbachol on a given test day). Inhaling carbachol at low LVi yielded a significantly (p less than 0.01) larger degree of bronchoconstriction. Differences in bronchial responses were probably due to differences in the amount of particles deposited in the airways and/or to their distribution. These data suggest that LVi should be controlled for quantified inhalation provocation tests.

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Accession: 005151949

PMID: 3589180

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Hellwig, Dieter; Kuhn, Thomas J.; Bauer, Bernhard L.; List Hellwig, Elisabeth, 1996: Endoscopic treatment of septated chronic subdural hematoma. BACKGROUND: Chronic subdural hematomas are well delineated collections of fluid (blood) between the dura mater and the arachnoid space. Two types of encapsulated chronic subdural hematoma can be distinguished: the nonseptated and the septated form...

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Oprandy, John J.; Amemiya, Kei; Kenten, John H.; Green, Richard G., 1994: Quantitation of HIV-1 and JC viral nucleic acids using an automated electrochemiluminescence-based detection system. AIDS Research & Human Retroviruses 10(SUPPL 3): S99

Coleman, W.B.; Throneburg, D.B.; Grisham, J.W.; Smith, G.J., 1994: Overexpression of c-K-ras, c-N-ras and transforming growth factor beta co-segregate with tumorigenicity in morphologically transformed C3H 10T1/2 cell lines. Morphologic transformation and tumorigenicity are separate cellular phenotypes in transformed 10T1/2 cells. We have investigated the levels of expression of genes for c-myc, c-H-ras, c-K-ras, c-N-ras, TGF beta and Rb in 42 morphologically transfor...

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Damian M. Stanley; Jennifer Cumming; Martyn Standage; Joan L. Duda, 2012: Images of exercising Exploring the links between exercise imagery use, autonomous and controlled motivation to exercise, and exercise intention and behavior. In the present study, we tested a model examining the relationships between exercise imagery use, motivational regulations for exercise engagement, intention to exercise, and self-reported exercise behavior. This work represents an initial attempt...

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