EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Different bronchoconstrictor effects of carbachol boluses inhaled near residual volume or total lung capacity


Respiration; International Review of Thoracic Diseases 51(2): 81-85
Different bronchoconstrictor effects of carbachol boluses inhaled near residual volume or total lung capacity
The purpose of this study was to determine if the lung volume at which aerosol inhalation begins (LVi) influences airway responses to bronchoconstrictor agents. We compared the effects of carbachol boluses (25, 50 and 100 ml), inhaled at high and low LVi (averaging 72.2 and 15.8% of vital capacity, respectively) on specific airway resistance (SRaw). In order to eliminate the possible influence of airway obstruction on aerosol distribution and deposition, we selected 5 asthmatic subjects with normal respiratory function (spirometry, SRaw, nitrogen washout and closing volume); furthermore, non-cumulative dose-response curves were obtained (i.e. the patients inhaled only one dose of carbachol on a given test day). Inhaling carbachol at low LVi yielded a significantly (p less than 0.01) larger degree of bronchoconstriction. Differences in bronchial responses were probably due to differences in the amount of particles deposited in the airways and/or to their distribution. These data suggest that LVi should be controlled for quantified inhalation provocation tests.


Accession: 005151949

PMID: 3589180



Related references

Pre treatment of exercise induced asthma with beta 2 agonists inhaled from residual volume to total lung capacity or at total lung capacity a preliminary report. European Journal of Respiratory Diseases Supplement 64(128 PART 2): 518-520, 1983

Reference values for residual volume, functional residual capacity and total lung capacity. ATS Workshop on Lung Volume Measurements. Official Statement of The European Respiratory Society. European Respiratory Journal 8(3): 492-506, 1995

Static lung volumes functional residual capacity residual volume and total lung capacity. Miller, A (Ed ) Pulmonary Function Tests in Clinical And Occupational Lung Disease Xiv+482p Grune And Stratton, Inc : Orlando, Fla , Usa (Dist in The United Kingdom By Grune And Stratton, Ltd : London, England) Illus 77-92, 1986

Full lung volumes functional residual capacity residual volume and total lung capacity. Miller, A (Ed ) Pulmonary Function Tests: A Guide For The Student And House Officer Xvii+275p Grune And Stratton, Inc : Orlando, Florida, Usa; London, England, Uk (Dist in The Uk By Grune And Stratton, Ltd : London, England) Illus Paper 53-58, 1987

Comparison of hydrostatic weighing at total lung capacity measured residual volume and predicted residual volume in older men. Medicine & Science in Sports & Exercise 15(2): 172-173, 1983

Total lung capacity, residual volume and predicted residual volume in a densitometric study of older men. British Journal of Sports Medicine 20(2): 66-68, 1986

Reference values for residual volume, functional residual capacity and total lung capacity. European Respiratory Journal 8(3): 492-506, 1995

Hydrostatic weighing at residual volume total lung capacity and functional residual capacity. Medicine & Science in Sports & Exercise 21(2 SUPPL): S100, 1989

Roentgenologic methods for lung volume determination and for the evaluation of the total lung capacity and the residual volume of the lungs. Radiologia Diagnostica 14(1): 107-111, 1973

Lung volume volume history and the distribution of inhaled boluses. Respiration Physiology 33(3): 279-288, 1978