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Different changes by acute electric footshock of opioid agonist and antagonist receptors in rat brain


, : Different changes by acute electric footshock of opioid agonist and antagonist receptors in rat brain. Neuroscience Letters 49(3): 307-312

Electric shock (ES) produces an opiate-like analgesia and catalepsy in rats, which may be mediated by endogenous opioid systems. The alterations of endogenous opioid receptors were investigated by an intermittent ES application. In a case of opiate agonists, [3H]dihydromorphine and [3H]D-Ala-Met-enkephalinamide, the application of ES produced a decrease of [3H]ligands' binding capacity. The binding capacity of the opiate antagonist [3H]naloxone was increased by the ES application. Endogenous putative opioid agonist- and antagonist-type receptors are differently regulated in vivo.

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Accession: 005151974

PMID: 6093006

DOI: 10.1016/0304-3940(84)90307-0

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