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Different cholinergic synapses converging onto neurons in aplysia californica produce the same synaptic action

Brain Research 199(2): 459-465

Different cholinergic synapses converging onto neurons in aplysia californica produce the same synaptic action

Neurons receiving inputs from more than 1 cholinergic interneuron were investigated to determine whether one cholinergic input can depolarize and the other hyperpolarize by activating different ACh [acetylcholine] receptors. Synapses made in the abdominal ganglion of A. californica by 3 cholinergic interneurons were examined; 2 of those interneurons were cholinergic. Using biochemical and pharmacological tests a 3rd interneuron was proven to be cholinergic. For 7 postsynaptic cells, 6 new connections identified from cholinergic interneurons and 12 known connections were compared. Different cholinergic inputs onto any given cell produced the same synaptic action in each case. L7, a cell with 2 types of ACh receptors, gave consistent responses. A postsynaptic cell apparently does not segregate different types of ACh receptors. This lack of segregation may help explain why a nervous system uses more than 1 neurotransmitter and why certain interneurons are needed in neural networks.

Accession: 005151988

Related references

Segal, M.; Koester, J., 1980: Different cholinergic synapses converging onto neurons in Aplysia produce the same synaptic action. We have investigated neurons that receive inputs from more than one cholinergic interneuron, to see whether one cholinergic input can depolarize and the other hyperpolarize by virtue of activating different ACh receptors. We have examined synapses...

Winfree, M.L.; Apland, J.P.; Shih, T.M.; Filbert, M.G., 1994: Changes in synaptic transmission produced by phospholipase A-2-neurotoxins in cholinergic pairs of neurons in Aplysia californica. Society for Neuroscience Abstracts 20(1-2): 1519

Segal M.M.; Koester J., 1982: Convergent cholinergic neurons produce similar postsynaptic actions in aplysia californica implications for neural organization. Neurons that receive convergent inputs from 2 or more cholinergic interneurons were investigated to see whether different cholinergic inputs to the same cell can activate selectively different types of acetylcholine (ACh) receptors. Synapses made...

Hawkins, R.D.; Castellucci, V.F.; Kandel, E.R., 1981: Inter neurons involved in mediation and modulation of gill withdrawal reflex in aplysia californica 2. neurons produce hetero synaptic facilitation contributing to behavioral sensitization. Sensory motor and interneurons that participate in mediation of the gill-withdrawal reflex of Aplysia were identified previously. Neurons (L22, L28 and L29) that produce heterosynaptic facilitation that probably contribute to modulation of that re...

Emptage, N.J.; Mauelshagen, J.; Carew, T.J., 1996: Threshold serotonin concentration required to produce synaptic facilitation differs for depressed and nondepressed synapses in Aplysia sensory neurons. 1. The modulatory actions produced by the neurotransmitter serotonin (5HT) in Aplysia sensory neurons (SNs) can be distinguished on the basis of their concentration requirement for 5HT, their activation and recovery kinetics, and their dependence...

Mothet, J.P.; Fossier, P.; Schirar, A.; Tauc, L.; Baux, G., 1996: Opposite effects of nitric oxide on identified inhibitory and excitatory cholinergic synapses of Aplysia californica. The effects of nitric oxide on evoked acetylcholine (ACh) release were studied at two identified cholinergic neuro-neuronal synapses of the nervous system of the mollusc Aplysia californica. The NO donor, 3-morpholinosydnonimine (SIN-1), decreased...

Newlin, SA., 1979: Presynaptic aminergic modulation of a synaptic plasticity at a presumably cholinergic synapse in Aplysia californica. Dissertation Abstracts International B Sciences and Engineering, 403: 1074

King W.M.; Kreisman N.R., 1981: Trimethadione effects on cholinergic responses in aplysia californica neurons. The anticonvulsant, trimethadione (TMO), was tested for effects on cholinergic responses to iontophoretic application of ACh on identified neurons in Aplysia. TMO (1-10 mM) depressed the amplitudes of depolarizing responses mediated by Na+ and hyp...

Bailey C.H.; Thompson E.B.; Kandel E.R.; Castellicci V.F., 1979: Ultrastructure of the synapses of sensory neurons that mediate the gill withdrawal reflex in aplysia californica. The processes of mechanoreceptor sensory neurons by intracellular injection of horseradish peroxidase was identified to study the structure of synapses which exhibit profound, behaviorally-relevant plasticity. These synapses are located at small,...

Rayport S.G.; Ambron R.T.; Babiarz J., 1983: Identified cholinergic neurons r 2 and lp 11 control mucus release in aplysia californica. R2 and LP11 are homologous giant cholinergic neurons in the nervous system of A. [californica] with overlapping and almost symmetrical axonal trees extending over most of the body wall. In spite of much experimental study, the behavioral role of t...