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Different cholinergic synapses converging onto neurons in aplysia californica produce the same synaptic action

Brain Research 199(2): 459-465

Different cholinergic synapses converging onto neurons in aplysia californica produce the same synaptic action

Neurons receiving inputs from more than 1 cholinergic interneuron were investigated to determine whether one cholinergic input can depolarize and the other hyperpolarize by activating different ACh [acetylcholine] receptors. Synapses made in the abdominal ganglion of A. californica by 3 cholinergic interneurons were examined; 2 of those interneurons were cholinergic. Using biochemical and pharmacological tests a 3rd interneuron was proven to be cholinergic. For 7 postsynaptic cells, 6 new connections identified from cholinergic interneurons and 12 known connections were compared. Different cholinergic inputs onto any given cell produced the same synaptic action in each case. L7, a cell with 2 types of ACh receptors, gave consistent responses. A postsynaptic cell apparently does not segregate different types of ACh receptors. This lack of segregation may help explain why a nervous system uses more than 1 neurotransmitter and why certain interneurons are needed in neural networks.

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Accession: 005151988

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