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Different cholinergic synapses converging onto neurons in aplysia californica produce the same synaptic action

, : Different cholinergic synapses converging onto neurons in aplysia californica produce the same synaptic action. Brain Research 199(2): 459-465

Neurons receiving inputs from more than 1 cholinergic interneuron were investigated to determine whether one cholinergic input can depolarize and the other hyperpolarize by activating different ACh [acetylcholine] receptors. Synapses made in the abdominal ganglion of A. californica by 3 cholinergic interneurons were examined; 2 of those interneurons were cholinergic. Using biochemical and pharmacological tests a 3rd interneuron was proven to be cholinergic. For 7 postsynaptic cells, 6 new connections identified from cholinergic interneurons and 12 known connections were compared. Different cholinergic inputs onto any given cell produced the same synaptic action in each case. L7, a cell with 2 types of ACh receptors, gave consistent responses. A postsynaptic cell apparently does not segregate different types of ACh receptors. This lack of segregation may help explain why a nervous system uses more than 1 neurotransmitter and why certain interneurons are needed in neural networks.

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Related references

Segal, M.; Koester, J., 1980: Different cholinergic synapses converging onto neurons in Aplysia produce the same synaptic action. We have investigated neurons that receive inputs from more than one cholinergic interneuron, to see whether one cholinergic input can depolarize and the other hyperpolarize by virtue of activating different ACh receptors. We have examined synapses...

Winfree, M.L.; Apland, J.P.; Shih, T.M.; Filbert, M.G., 1994: Changes in synaptic transmission produced by phospholipase A-2-neurotoxins in cholinergic pairs of neurons in Aplysia californica. Society for Neuroscience Abstracts 20(1-2): 1519

Segal M.M.; Koester J., 1982: Convergent cholinergic neurons produce similar postsynaptic actions in aplysia californica implications for neural organization. Neurons that receive convergent inputs from 2 or more cholinergic interneurons were investigated to see whether different cholinergic inputs to the same cell can activate selectively different types of acetylcholine (ACh) receptors. Synapses made...

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Emptage, N.J.; Mauelshagen, J.; Carew, T.J., 1996: Threshold serotonin concentration required to produce synaptic facilitation differs for depressed and nondepressed synapses in Aplysia sensory neurons. 1. The modulatory actions produced by the neurotransmitter serotonin (5HT) in Aplysia sensory neurons (SNs) can be distinguished on the basis of their concentration requirement for 5HT, their activation and recovery kinetics, and their dependence...

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King W.M.; Kreisman N.R., 1981: Trimethadione effects on cholinergic responses in aplysia californica neurons. The anticonvulsant, trimethadione (TMO), was tested for effects on cholinergic responses to iontophoretic application of ACh on identified neurons in Aplysia. TMO (1-10 mM) depressed the amplitudes of depolarizing responses mediated by Na+ and hyp...

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