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Different classes of antibody activities to trichosporon cutaneum antigen in summer type hypersensitivity pneumonitis by elisa


, : Different classes of antibody activities to trichosporon cutaneum antigen in summer type hypersensitivity pneumonitis by elisa. American Review of Respiratory Disease 133(1): 83-87

To assess the diagnostic value of antibody activities to Trichosporon cutaneum antigen in patients with summer-type hypersensitivity pneumonitis in Japan, we measured the serum IgG, IgA, and IgM antibodies to saline-soluble antigen of homogenized T. cutaneum cells by enzyme-linked immunosorbent assay (ELISA). The IgG antibody activity was observed in serum samples from 25 (83%) of the 30 patients and in 9 (82%) of the 11 asymptomatic family members. The IgA antibody activity was found in 25 (83%) of the patients but in only 3 (27%) of asymptomatic family members. Unexpectedly, we found no significant correlation between the IgG and IgA antibody activities to the same antigen in individual patients. Moreover, although the IgG antibody activity was related to the precipitating antibody, the IgA antibody activity was not. The IgM antibody activity by ELISA was found in only 5 (17%) of the patients. The IgG+IgA+IgM antibody activity was demonstrated in 27 (90%) of the 30 patients, and of 3 serum samples that were found negative by the ELISA method, 2 were positive by the IFA method. We conclude that the detection of the serum IgG and IgA antibody activities to T. cutaneum antigen by ELISA is a simple and useful serodiagnostic test for summer-type hypersensitivity pneumonitis. Measurement of the IgA antibody activity is especially helpful in discriminating symptomatic from asymptomatic family members.


Accession: 005151999

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Related references

Soda, K.; Ando, M.; Shimazu, K.; Sakata, T.; Yoshida, K.; Araki, S., 1986: Different classes of antibody activities to Trichosporon cutaneum antigen in summer-type hypersensitivity pneumonitis by enzyme-linked immunosorbent assay. To assess the diagnostic value of antibody activities to Trichosporon cutaneum antigen in patients with summer-type hypersensitivity pneumonitis in Japan, we measured the serum IgG, IgA, and IgM antibodies to saline-soluble antigen of homogenized...

Soda, K.; Ando, M.; Yoshida, K.; Sakata, T.; Sugimoto, M.; Nakashima, H.; Nishi, R.; Araki, S., 1987: Anti-Trichosporon cutaneum IgG, IgA and s-IgA antibody activities in bronchoalveolar lavage fluids in summer-type hypersensitivity pneumonitis. Nihon Kyobu Shikkan Gakkai Zasshi 25(1): 112-118

Arima, K.; Ando, M.; Yoshida, K.; Sakata, T.; Sugimoto, M.; Araki, S.; Futatsuka, M., 1990: Suppressive effects of cigarette smoking on the prevalence of summer-type hypersensitivity pneumonitis caused by Trichosporon cutaneum and specific antibody response to the antigen. The effect of cigarette smoking on the prevalence of summer-type hypersensitivity pneumonitis (HP) caused by T. cutaneum [T. beigelii] and the specific antibody response to the antigen were studied. Study groups (n=3) were established: HP group (n...

Ando, M.; Sakata, T.; Yamasaki, H.; Arima, K.; Mizobe, T.; Sugimoto, M.; Araki, S.; Onoue, K., 1990: Serotype-related polysaccharide antigen of Trichosporon cutaneum in the induction of summer-type hypersensitivity pneumonitis. The role of the serotype related polysaccharide antigen of T. cutaneum [T. beigelii] in the induction of summer-type hypersensitivity pneumonitis (HP) was evaluated. Summer-type HP patients (n=7) were included in the study after consenting to the...

Sakata, T.; Ando, M.; Yoshida, K.; Soda, K.; Araki, S.; Shinoda, T.; Ikeda, R.; Kojima, N.; Sakai, H., 1988: Summer-type hypersensitivity pneumonitis induced by Trichosporon cutaneum in terms of the role of serotype on the antigen. Nihon Kyobu Shikkan Gakkai Zasshi 26(2): 123-128

Ando, M.; Yoshida, K.; Soda, K.; Araki, S., 1986: Specific bronchoalveolar lavage IgA antibody in patients with summer-type hypersensitivity pneumonitis induced by Trichosporon cutaneum. Two cases in a mother and daughter are reported. T. cutaneum [T. beigelii] was isolated from the pillow of 1 patient. The specific IgG, IgA and secretory IgA (S-IgA) antibodies to T. beigelii in serum and bronchoalveolar lavage fluid (BALF) in the...

Araki S., 1986: Specific bronchoalveolar lavage immunoglobulin a antibody in patients with summer type hypersensitivity pneumonitis induced by trichosporon cutaneum. American Review Of Respiratory Disease: 177-179

Shimazu, K.; Ando, M.; Sakata, T.; Yoshida, K.; Araki, S., 1984: Hypersensitivity pneumonitis induced by Trichosporon cutaneum--a proposal of the etiologic agent of summer-type hypersensitivity pneumonitis. Nihon Kyobu Shikkan Gakkai Zasshi 22(6): 491-500

Miyake, S.; Hamaoka, A.; Yoshizawa, Y., 2001: Clinical usefulness of antigen-captured ELISA method using mouse anti-Trichosporon asahii monoclonal antibody D-8 for diagnosis of summer-type hypersensitivity pneumonitis. In the present study, we assessed the clinical usefulness of the antigen-captured ELISA method using mouse anti-Trichosporon asahii monoclonal antibody D-8 in 193 patients with summer-type hypersensitivity pneumonitis (SHP) and in 127 healthy volu...

Mizobe, T.; Ando, M.; Yamasaki, H.; Onoue, K.; Misaki, A., 1995: Purification and characterization of the serotype-specific polysaccharide antigen of Trichosporon cutaneum serotype II: a disease-related antigen of Japanese summer-type hypersensitivity pneumonitis. Summer-type hypersensitivity pneumonitis (SHP) is a unique type of hypersensitivity pneumonitis and the most prevalent in Japan. Our previous study clarified that the causative agent of the disease is Trichosporon cutaneum, and that the patients w...